抗人 PD1 抗体对
01AB02399
Programmed Cell Death 1 (PDCD1), also known as PD-1 or CD279, is a cell surface receptor that plays a critical role in regulating the immune system's response to the body's own cells. It is encoded by the PDCD1 gene and belongs to the immunoglobulin superfamily. PD-1 is primarily expressed on activated T cells, B cells, and macrophages, where it binds to its ligands PD-L1 and PD-L2. By interacting with these ligands, PD-1 negatively regulates immune responses, preventing autoimmune diseases but potentially allowing cancer cells to evade immune attack. PD-1 inhibits T cell receptor signaling, promotes apoptosis of antigen-specific T cells, and reduces apoptosis in regulatory T cells.
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技术参数
- 靶点基因名
- PDCD1
- 基因别名
- PD1
- 蛋白别名
- programmed cell death 1; PD1
- UniProt
- Q15116
- 物种
- Human
产品详情
- 靶点名称
- PD1
- 蛋白名称
- programmed cell death 1
- 蛋白别名
- Programmed cell death protein 1; Protein PD-1; hPD-1; CD antigen CD279
- 靶点基因名
- PDCD1
- 基因别名
- PD1
- UniProt
- Q15116
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Programmed Cell Death 1 (PDCD1), also known as PD-1 or CD279, is a cell surface receptor that plays a critical role in regulating the immune system's response to the body's own cells. It is encoded by the PDCD1 gene and belongs to the immunoglobulin superfamily. PD-1 is primarily expressed on activated T cells, B cells, and macrophages, where it binds to its ligands PD-L1 and PD-L2. By interacting with these ligands, PD-1 negatively regulates immune responses, preventing autoimmune diseases but potentially allowing cancer cells to evade immune attack. PD-1 inhibits T cell receptor signaling, promotes apoptosis of antigen-specific T cells, and reduces apoptosis in regulatory T cells.