抗人 PD-L1 抗体对
01AB00757
CD274 encodes the protein PD-L1, which is an immune inhibitory receptor ligand expressed by various cells, including T cells, B cells, and tumor cells. The interaction of PD-L1 with its receptor PD-1 on activated T cells transmits an inhibitory signal that reduces T cell proliferation and activation, helping to maintain immune homeostasis. However, in the tumor microenvironment, this interaction allows tumor cells to evade immune surveillance and escape destruction by cytotoxic T cells. Disorders in the expression and regulation of CD274/PD-L1 have been associated with various diseases. Overexpression of PD-L1 in tumors is linked to immune escape and worse prognosis in many cancers. Conversely, downregulation of PD-L1 has been observed in autoimmune diseases like systemic lupus erythematosus, potentially contributing to loss of peripheral tolerance. Overall, CD274/PD-L1 plays a critical role in modulating immune responses, with implications for both cancer and autoimmunity.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- CD274
- 基因别名
- B7H1; PDCD1L1; PDCD1LG1; PDL1
- 蛋白别名
- CD274 molecule; PD-L1
- UniProt
- Q9NZQ7
- 物种
- Human
产品详情
- 靶点名称
- PD-L1
- 蛋白名称
- CD274 molecule
- 蛋白别名
- Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; hPD-L1; B7 homolog 1; B7-H1; CD antigen CD274
- 靶点基因名
- CD274
- 基因别名
- B7H1; PDCD1L1; PDCD1LG1; PDL1
- UniProt
- Q9NZQ7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
CD274 encodes the protein PD-L1, which is an immune inhibitory receptor ligand expressed by various cells, including T cells, B cells, and tumor cells. The interaction of PD-L1 with its receptor PD-1 on activated T cells transmits an inhibitory signal that reduces T cell proliferation and activation, helping to maintain immune homeostasis. However, in the tumor microenvironment, this interaction allows tumor cells to evade immune surveillance and escape destruction by cytotoxic T cells. Disorders in the expression and regulation of CD274/PD-L1 have been associated with various diseases. Overexpression of PD-L1 in tumors is linked to immune escape and worse prognosis in many cancers. Conversely, downregulation of PD-L1 has been observed in autoimmune diseases like systemic lupus erythematosus, potentially contributing to loss of peripheral tolerance. Overall, CD274/PD-L1 plays a critical role in modulating immune responses, with implications for both cancer and autoimmunity.