人 PCDH10 抗体对
01AB03154
Protocadherin-10 (PCDH10) is a calcium-dependent cell-adhesion protein of the non-clustered delta-protocadherin subfamily. Predominantly expressed in the nervous system, it functions as a receptor involved in establishing specific neuronal connections and regulating cell motility. In oncology, PCDH10 acts as a broad-spectrum tumor suppressor. Its promoter is frequently silenced by hypermethylation in multiple malignancies, including nasopharyngeal, gastric, and lung cancers. This epigenetic silencing correlates with increased tumor invasion, metastasis, and chemoresistance, identifying PCDH10 as a significant prognostic marker and potential therapeutic target.
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技术参数
- 靶点基因名
- PCDH10
- 基因别名
- KIAA1400
- 蛋白别名
- protocadherin 10; PCDH10
- UniProt
- Q9P2E7
- 物种
- Human
产品详情
- 靶点名称
- PCDH10
- 蛋白名称
- protocadherin 10
- 蛋白别名
- Protocadherin-10
- 靶点基因名
- PCDH10
- 基因别名
- KIAA1400
- UniProt
- Q9P2E7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protocadherin-10 (PCDH10) is a calcium-dependent cell-adhesion protein of the non-clustered delta-protocadherin subfamily. Predominantly expressed in the nervous system, it functions as a receptor involved in establishing specific neuronal connections and regulating cell motility. In oncology, PCDH10 acts as a broad-spectrum tumor suppressor. Its promoter is frequently silenced by hypermethylation in multiple malignancies, including nasopharyngeal, gastric, and lung cancers. This epigenetic silencing correlates with increased tumor invasion, metastasis, and chemoresistance, identifying PCDH10 as a significant prognostic marker and potential therapeutic target.