抗人 PARP1 抗体对

靶点名称

PARP1

蛋白名称

poly(ADP-ribose) polymerase 1

蛋白别名

Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1) [Cleaved into: Poly [ADP-ribose] polymerase 1; processed C-terminus; Poly [ADP-ribose] polymerase 1; 89-kDa form; Poly [ADP-ribose] polymerase 1; processed N-terminus; NT-PARP-1; Poly [ADP-ribose] polymerase 1; 24-kDa form; Poly [ADP-ribose] polymerase 1; 28-kDa form]

靶点基因名

PARP1

基因别名

ADPRT; PPOL

UniProt

P09874

来源物种

Homo sapiens (Human)

物种反应性

Human

背景介绍

Poly [ADP-ribose] polymerase 1 (PARP1) is a critical enzyme involved in the cellular response to DNA damage, primarily functioning as an ADP-ribosylating enzyme that synthesizes poly(ADP-ribose) (PAR) chains from NAD+. This process is essential for the recruitment of DNA repair proteins to sites of damage, facilitating various DNA repair pathways, including base excision repair and homologous recombination. PARP1's activity is crucial for maintaining genomic stability and cellular integrity. Dysregulation of PARP1 has been implicated in several diseases, particularly cancer, where its overactivity can lead to tumorigenesis by promoting cell survival despite DNA damage. Beyond cancer, PARP1 is also involved in inflammatory responses and has been linked to neurodegenerative diseases.