抗人 PAR6 抗体对
01AB02752
Par-6 family cell polarity regulator alpha (PAR6α), encoded by PARD6A, is a cytoplasmic scaffold protein that is a core component of the evolutionarily conserved Par3–Par6–atypical PKC (aPKC) polarity complex. It contains an N‑terminal PB1 domain that heterodimerizes with aPKC, a semi‑CRIB motif binding active Cdc42/Rac1, and a C‑terminal PDZ domain that associates with Par3 and other polarity proteins, thereby linking Cdc42 to Par3–aPKC and organizing tight junctions and apical–basal polarity in epithelial cells. Through this complex, PAR6α regulates epithelial morphogenesis, directional migration, axon specification, and coupling of polarity to apoptosis via an aPKC–GSK3β pathway. PAR6 overexpression induces epidermal growth factor–independent proliferation of mammary epithelial cells by activating MEK/ERK signaling and is frequently upregulated in precancerous breast lesions and estrogen receptor–positive breast cancers, where it promotes hyperplastic acinar growth and contributes to tumor initiation and progression.
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技术参数
- 靶点基因名
- PARD6A
- 基因别名
- PAR6A
- 蛋白别名
- par-6 family cell polarity regulator alpha; PAR6
- UniProt
- Q9NPB6
- 物种
- Human
产品详情
- 靶点名称
- PAR6
- 蛋白名称
- par-6 family cell polarity regulator alpha
- 蛋白别名
- Partitioning defective 6 homolog alpha; PAR-6; PAR-6 alpha; PAR-6A; PAR6C; Tax interaction protein 40; TIP-40
- 靶点基因名
- PARD6A
- 基因别名
- PAR6A
- UniProt
- Q9NPB6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Par-6 family cell polarity regulator alpha (PAR6α), encoded by PARD6A, is a cytoplasmic scaffold protein that is a core component of the evolutionarily conserved Par3–Par6–atypical PKC (aPKC) polarity complex. It contains an N‑terminal PB1 domain that heterodimerizes with aPKC, a semi‑CRIB motif binding active Cdc42/Rac1, and a C‑terminal PDZ domain that associates with Par3 and other polarity proteins, thereby linking Cdc42 to Par3–aPKC and organizing tight junctions and apical–basal polarity in epithelial cells. Through this complex, PAR6α regulates epithelial morphogenesis, directional migration, axon specification, and coupling of polarity to apoptosis via an aPKC–GSK3β pathway. PAR6 overexpression induces epidermal growth factor–independent proliferation of mammary epithelial cells by activating MEK/ERK signaling and is frequently upregulated in precancerous breast lesions and estrogen receptor–positive breast cancers, where it promotes hyperplastic acinar growth and contributes to tumor initiation and progression.