人 PAICS 抗体对
01AB02242
Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS) is a bifunctional cytosolic enzyme essential for the de novo purine biosynthetic pathway. It catalyzes the sequential conversion of aminoimidazole ribotide (AIR) to carboxyaminoimidazole ribotide (CAIR) and subsequently to succinylaminoimidazolecarboxamide ribotide (SAICAR). Structurally, PAICS forms a homo-octamer that enables efficient substrate channeling between its carboxylase and synthetase domains. The enzyme is a key component of the purinosome, a multienzyme complex that assembles to meet high cellular demands for purines. Clinically, PAICS is overexpressed in numerous malignancies, including lung adenocarcinoma and prostate cancer, where it promotes metabolic reprogramming, cell proliferation, and epithelial-mesenchymal transition.
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技术参数
- 靶点基因名
- PAICS
- 基因别名
- ADE2; AIRC; PAIS
- 蛋白别名
- phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase; PAICS
- UniProt
- P22234
- 物种
- Human
产品详情
- 靶点名称
- PAICS
- 蛋白名称
- phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
- 蛋白别名
- Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase; SAICAR synthetase]
- 靶点基因名
- PAICS
- 基因别名
- ADE2; AIRC; PAIS
- UniProt
- P22234
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (PAICS) is a bifunctional cytosolic enzyme essential for the de novo purine biosynthetic pathway. It catalyzes the sequential conversion of aminoimidazole ribotide (AIR) to carboxyaminoimidazole ribotide (CAIR) and subsequently to succinylaminoimidazolecarboxamide ribotide (SAICAR). Structurally, PAICS forms a homo-octamer that enables efficient substrate channeling between its carboxylase and synthetase domains. The enzyme is a key component of the purinosome, a multienzyme complex that assembles to meet high cellular demands for purines. Clinically, PAICS is overexpressed in numerous malignancies, including lung adenocarcinoma and prostate cancer, where it promotes metabolic reprogramming, cell proliferation, and epithelial-mesenchymal transition.