人 PAGE1 抗体对
01AB00552
PAGE Family Member 1 (PAGE1), encoded by the PAGE1 gene, is a cancer-testis antigen predominantly expressed in normal testicular germ cells and aberrantly activated in various cancers, including melanoma, hepatocellular carcinoma (HCC), and lung cancer. Located on chromosome Xp11.23, PAGE1 belongs to the GAGE/PAGE protein family, which is characterized by germline-specific expression and immunogenic properties. PAGE1 is implicated in immune evasion and apoptosis modulation, potentially promoting tumor survival. In melanoma, PAGE1 overexpression correlates with advanced disease stages and poorer prognosis, suggesting its role in tumor progression. Similarly, in HCC, elevated PAGE1 levels are observed in tumor tissues compared to healthy liver, linking it to oncogenic processes.
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技术参数
- 靶点基因名
- PAGE1
- 基因别名
- GAGE9; GAGEB1
- 蛋白别名
- PAGE family member 1; PAGE1
- UniProt
- O75459
- 物种
- Human
产品详情
- 靶点名称
- PAGE1
- 蛋白名称
- PAGE family member 1
- 蛋白别名
- P antigen family member 1; PAGE-1; AL5; G antigen 9; GAGE-9; G antigen family B member 1; Prostate-associated gene 1 protein
- 靶点基因名
- PAGE1
- 基因别名
- GAGE9; GAGEB1
- UniProt
- O75459
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
PAGE Family Member 1 (PAGE1), encoded by the PAGE1 gene, is a cancer-testis antigen predominantly expressed in normal testicular germ cells and aberrantly activated in various cancers, including melanoma, hepatocellular carcinoma (HCC), and lung cancer. Located on chromosome Xp11.23, PAGE1 belongs to the GAGE/PAGE protein family, which is characterized by germline-specific expression and immunogenic properties. PAGE1 is implicated in immune evasion and apoptosis modulation, potentially promoting tumor survival. In melanoma, PAGE1 overexpression correlates with advanced disease stages and poorer prognosis, suggesting its role in tumor progression. Similarly, in HCC, elevated PAGE1 levels are observed in tumor tissues compared to healthy liver, linking it to oncogenic processes.