抗人 PADI2 抗体对
01AB03355
Protein-arginine deiminase type-2 (PADI2) is an enzyme that catalyzes the post-translational modification known as citrullination, where arginine residues in proteins are converted to citrulline in a calcium-dependent manner. This modification alters protein structure and function, influencing various biological processes such as gene expression, cell signaling, and immune responses. PADI2 is widely expressed in tissues, particularly in the central nervous system and immune cells, where it plays a crucial role in macrophage function, including cytokine secretion and apoptosis. Dysregulation of PADI2 has been implicated in several diseases, notably autoimmune disorders like rheumatoid arthritis and multiple sclerosis, where abnormal citrullination can lead to the generation of autoantigens. Additionally, PADI2 has been associated with cancer progression, as its activity can modulate transcription factors involved in tumorigenesis.
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技术参数
- 靶点基因名
- PADI2
- 基因别名
- KIAA0994; PAD2; PDI2
- 蛋白别名
- peptidyl arginine deiminase 2; PADI2
- UniProt
- Q9Y2J8
- 物种
- Human
产品详情
- 靶点名称
- PADI2
- 蛋白名称
- peptidyl arginine deiminase 2
- 蛋白别名
- Protein-arginine deiminase type-2; PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II
- 靶点基因名
- PADI2
- 基因别名
- KIAA0994; PAD2; PDI2
- UniProt
- Q9Y2J8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Protein-arginine deiminase type-2 (PADI2) is an enzyme that catalyzes the post-translational modification known as citrullination, where arginine residues in proteins are converted to citrulline in a calcium-dependent manner. This modification alters protein structure and function, influencing various biological processes such as gene expression, cell signaling, and immune responses. PADI2 is widely expressed in tissues, particularly in the central nervous system and immune cells, where it plays a crucial role in macrophage function, including cytokine secretion and apoptosis. Dysregulation of PADI2 has been implicated in several diseases, notably autoimmune disorders like rheumatoid arthritis and multiple sclerosis, where abnormal citrullination can lead to the generation of autoantigens. Additionally, PADI2 has been associated with cancer progression, as its activity can modulate transcription factors involved in tumorigenesis.