人 p53 抗体对
01AB03726
Cellular tumor antigen p53 (TP53) is a crucial tumor suppressor protein. It functions primarily as a transcription factor that regulates the expression of genes involved in cell cycle control, DNA repair, apoptosis, and cellular stress responses. The p53 protein is activated in response to various stress signals, such as DNA damage and oncogene activation, leading to cell cycle arrest or programmed cell death to prevent the proliferation of potentially cancerous cells. Mutations in the TP53 gene are the most common alterations found in human cancers, with significant implications for tumor development and progression. These mutations often result in a dysfunctional p53 protein that fails to regulate cell growth effectively, allowing cells with damaged DNA to continue dividing uncontrollably. Consequently, TP53 mutations are associated with various cancers, including breast, lung, and colorectal cancers.
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技术参数
- 靶点基因名
- TP53
- 基因别名
- P53
- 蛋白别名
- tumor protein p53; p53
- UniProt
- P04637
- 物种
- Human
产品详情
- 靶点名称
- p53
- 蛋白名称
- tumor protein p53
- 蛋白别名
- Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
- 靶点基因名
- TP53
- 基因别名
- P53
- UniProt
- P04637
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Cellular tumor antigen p53 (TP53) is a crucial tumor suppressor protein. It functions primarily as a transcription factor that regulates the expression of genes involved in cell cycle control, DNA repair, apoptosis, and cellular stress responses. The p53 protein is activated in response to various stress signals, such as DNA damage and oncogene activation, leading to cell cycle arrest or programmed cell death to prevent the proliferation of potentially cancerous cells. Mutations in the TP53 gene are the most common alterations found in human cancers, with significant implications for tumor development and progression. These mutations often result in a dysfunctional p53 protein that fails to regulate cell growth effectively, allowing cells with damaged DNA to continue dividing uncontrollably. Consequently, TP53 mutations are associated with various cancers, including breast, lung, and colorectal cancers.