抗人 OTOR 抗体对
01AB01540
Otoraplin (OTOR) is a secreted cytokine protein of approximately 12.7–16 kDa, encoded by the OTOR gene, and a member of the MIA/OTOR family characterized by a Src homology-3 (SH3)-like domain. It is predominantly expressed in the cochlea of the inner ear, periotic mesenchyme, developing and mature fibrocytes, and to a lesser extent in fetal brain and cartilage tissues. Otoraplin plays a critical role in cartilage development and maintenance, particularly in the early chondrogenesis of the otic capsule, essential for normal inner ear formation and auditory function. Functionally, it regulates cell migration in a concentration-dependent manner and has homology to melanoma inhibitory activity proteins, suggesting involvement in tumor biology. Clinically, mutations or polymorphisms in OTOR are linked to hearing disorders such as otosclerosis and cochlear dysfunction, likely due to impaired cartilage and otic capsule development. Additionally, OTOR expression correlates with breast carcinoma prognosis, influencing cell proliferation, migration, and invasiveness.
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技术参数
- 靶点基因名
- OTOR
- 基因别名
- FDP; MIAL
- 蛋白别名
- otoraplin; OTOR
- UniProt
- Q9NRC9
- 物种
- Human
产品详情
- 靶点名称
- OTOR
- 蛋白名称
- otoraplin
- 蛋白别名
- Otoraplin; Fibrocyte-derived protein; Melanoma inhibitory activity-like protein
- 靶点基因名
- OTOR
- 基因别名
- FDP; MIAL
- UniProt
- Q9NRC9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Otoraplin (OTOR) is a secreted cytokine protein of approximately 12.7–16 kDa, encoded by the OTOR gene, and a member of the MIA/OTOR family characterized by a Src homology-3 (SH3)-like domain. It is predominantly expressed in the cochlea of the inner ear, periotic mesenchyme, developing and mature fibrocytes, and to a lesser extent in fetal brain and cartilage tissues. Otoraplin plays a critical role in cartilage development and maintenance, particularly in the early chondrogenesis of the otic capsule, essential for normal inner ear formation and auditory function. Functionally, it regulates cell migration in a concentration-dependent manner and has homology to melanoma inhibitory activity proteins, suggesting involvement in tumor biology. Clinically, mutations or polymorphisms in OTOR are linked to hearing disorders such as otosclerosis and cochlear dysfunction, likely due to impaired cartilage and otic capsule development. Additionally, OTOR expression correlates with breast carcinoma prognosis, influencing cell proliferation, migration, and invasiveness.