人 OSCAR 抗体对
01AB04113
Osteoclast-associated immunoglobulin-like receptor (OSCAR) is a type I transmembrane protein primarily expressed on osteoclasts and some immune cells, playing a vital role in bone remodeling and immune regulation. Belonging to the immunoglobulin superfamily, OSCAR functions as a receptor that enhances osteoclast differentiation and activity through its interaction with specific ligands, which promotes bone resorption. It is particularly important in maintaining bone homeostasis by mediating the effects of cytokines and other signaling molecules involved in osteoclastogenesis. Additionally, OSCAR is implicated in the regulation of immune responses, influencing the interplay between bone and immune systems. Dysregulation of OSCAR expression or function can lead to various pathological conditions, including osteoporosis, where excessive osteoclast activity results in bone loss. Furthermore, it has been associated with inflammatory diseases such as rheumatoid arthritis, where increased OSCAR signaling contributes to joint destruction.
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技术参数
- 靶点基因名
- OSCAR
- 蛋白别名
- osteoclast associated Ig-like receptor; OSCAR
- UniProt
- Q8IYS5
- 物种
- Human
产品详情
- 靶点名称
- OSCAR
- 蛋白名称
- osteoclast associated Ig-like receptor
- 蛋白别名
- Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; hOSCAR; Polymeric immunoglobulin receptor 3; PIgR-3; PIgR3; Poly-Ig receptor 3
- 靶点基因名
- OSCAR
- UniProt
- Q8IYS5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Osteoclast-associated immunoglobulin-like receptor (OSCAR) is a type I transmembrane protein primarily expressed on osteoclasts and some immune cells, playing a vital role in bone remodeling and immune regulation. Belonging to the immunoglobulin superfamily, OSCAR functions as a receptor that enhances osteoclast differentiation and activity through its interaction with specific ligands, which promotes bone resorption. It is particularly important in maintaining bone homeostasis by mediating the effects of cytokines and other signaling molecules involved in osteoclastogenesis. Additionally, OSCAR is implicated in the regulation of immune responses, influencing the interplay between bone and immune systems. Dysregulation of OSCAR expression or function can lead to various pathological conditions, including osteoporosis, where excessive osteoclast activity results in bone loss. Furthermore, it has been associated with inflammatory diseases such as rheumatoid arthritis, where increased OSCAR signaling contributes to joint destruction.