人 OLR1 抗体对
01AB02232
Oxidized low-density lipoprotein receptor 1 (OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX-1). This receptor is a member of the C-type lectin superfamily and primarily functions in the recognition and internalization of oxidized low-density lipoprotein (oxLDL), which plays a significant role in atherosclerosis. OLR1 is predominantly expressed on vascular endothelial cells, macrophages, and smooth muscle cells, and its expression can be upregulated by various stimuli, including tumor necrosis factor-alpha and shear stress from blood flow. The binding of oxLDL to LOX-1 activates signaling pathways that lead to endothelial dysfunction, monocyte adhesion, and subsequent foam cell formation, which are critical steps in atherogenesis. Additionally, mutations in the OLR1 gene have been linked to increased risks of cardiovascular diseases, such as myocardial infarction, and may influence the risk of Alzheimer's disease.
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技术参数
- 靶点基因名
- OLR1
- 基因别名
- CLEC8A; LOX1
- 蛋白别名
- oxidized low density lipoprotein receptor 1; OLR1
- UniProt
- P78380
- 物种
- Human
产品详情
- 靶点名称
- OLR1
- 蛋白名称
- oxidized low density lipoprotein receptor 1
- 蛋白别名
- Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; hLOX-1; Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1; soluble form]
- 靶点基因名
- OLR1
- 基因别名
- CLEC8A; LOX1
- UniProt
- P78380
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Oxidized low-density lipoprotein receptor 1 (OLR1), also known as lectin-type oxidized LDL receptor 1 (LOX-1). This receptor is a member of the C-type lectin superfamily and primarily functions in the recognition and internalization of oxidized low-density lipoprotein (oxLDL), which plays a significant role in atherosclerosis. OLR1 is predominantly expressed on vascular endothelial cells, macrophages, and smooth muscle cells, and its expression can be upregulated by various stimuli, including tumor necrosis factor-alpha and shear stress from blood flow. The binding of oxLDL to LOX-1 activates signaling pathways that lead to endothelial dysfunction, monocyte adhesion, and subsequent foam cell formation, which are critical steps in atherogenesis. Additionally, mutations in the OLR1 gene have been linked to increased risks of cardiovascular diseases, such as myocardial infarction, and may influence the risk of Alzheimer's disease.