人 ODC1 抗体对
01AB00329
Ornithine decarboxylase 1 (ODC1) is a crucial enzyme in polyamine biosynthesis, catalyzing the first and rate-limiting step that converts ornithine into putrescine, a precursor for polyamines such as spermidine and spermine. The protein consists of 461 amino acids and forms a homodimer, with each monomer containing a barrel domain and a sheet domain connected by loops. ODC1 is essential for cell growth, stabilizing DNA structure, and DNA double-strand break repair pathways. Misregulation of ODC1 is associated with tumorigenic growth properties and is upregulated in various cancers, making it a potential target for cancer therapy. Additionally, mutations in the ODC1 gene can cause Bachmann-Bupp syndrome, a rare neurometabolic disorder characterized by developmental delay, alopecia, macrocephaly, and behavioral abnormalities.
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技术参数
- 靶点基因名
- ODC1
- 蛋白别名
- ornithine decarboxylase 1; ODC1
- UniProt
- P11926
- 物种
- Human
产品详情
- 靶点名称
- ODC1
- 蛋白名称
- ornithine decarboxylase 1
- 蛋白别名
- Ornithine decarboxylase; ODC
- 靶点基因名
- ODC1
- UniProt
- P11926
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ornithine decarboxylase 1 (ODC1) is a crucial enzyme in polyamine biosynthesis, catalyzing the first and rate-limiting step that converts ornithine into putrescine, a precursor for polyamines such as spermidine and spermine. The protein consists of 461 amino acids and forms a homodimer, with each monomer containing a barrel domain and a sheet domain connected by loops. ODC1 is essential for cell growth, stabilizing DNA structure, and DNA double-strand break repair pathways. Misregulation of ODC1 is associated with tumorigenic growth properties and is upregulated in various cancers, making it a potential target for cancer therapy. Additionally, mutations in the ODC1 gene can cause Bachmann-Bupp syndrome, a rare neurometabolic disorder characterized by developmental delay, alopecia, macrocephaly, and behavioral abnormalities.