人 Oct-2 抗体对
01AB01303
POU class 2 homeobox 2 (POU2F2) is a transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'), a sequence commonly found in immunoglobulin gene promoters, and plays a crucial role in regulating gene expression in B cells, particularly influencing their proliferation and differentiation. As a member of the POU transcription factor family, POU2F2 is essential for immune response modulation and can regulate the expression of genes such as IL6 in B cells. Structurally, it contains a POU-specific domain and a homeobox domain, enabling precise DNA binding and transcriptional activation. Beyond its physiological roles, POU2F2 has been implicated in cancer biology, where its overexpression is associated with tumor-promoting activities, such as enhancing cell proliferation, motility, and glycolytic reprogramming, notably in glioblastoma and lung cancer. Mechanistically, POU2F2 can activate the PI3K/AKT/mTOR pathway, contributing to tumor progression and poor prognosis in certain cancers.
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技术参数
- 靶点基因名
- POU2F2
- 基因别名
- OCT2; OTF2
- 蛋白别名
- POU class 2 homeobox 2; Oct-2
- UniProt
- P09086
- 物种
- Human
产品详情
- 靶点名称
- Oct-2
- 蛋白名称
- POU class 2 homeobox 2
- 蛋白别名
- POU domain; class 2; transcription factor 2; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2; OTF-2
- 靶点基因名
- POU2F2
- 基因别名
- OCT2; OTF2
- UniProt
- P09086
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
POU class 2 homeobox 2 (POU2F2) is a transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'), a sequence commonly found in immunoglobulin gene promoters, and plays a crucial role in regulating gene expression in B cells, particularly influencing their proliferation and differentiation. As a member of the POU transcription factor family, POU2F2 is essential for immune response modulation and can regulate the expression of genes such as IL6 in B cells. Structurally, it contains a POU-specific domain and a homeobox domain, enabling precise DNA binding and transcriptional activation. Beyond its physiological roles, POU2F2 has been implicated in cancer biology, where its overexpression is associated with tumor-promoting activities, such as enhancing cell proliferation, motility, and glycolytic reprogramming, notably in glioblastoma and lung cancer. Mechanistically, POU2F2 can activate the PI3K/AKT/mTOR pathway, contributing to tumor progression and poor prognosis in certain cancers.