人 OAZ1 抗体对
01AB01268
Ornithine decarboxylase antizyme 1 (OAZ1) is a regulatory protein that plays a crucial role in controlling intracellular polyamine levels by negatively regulating ornithine decarboxylase (ODC) activity and polyamine uptake, thereby influencing cell growth and proliferation. OAZ1 is widely expressed in human tissues and is part of the antizyme family, which modulates polyamine biosynthesis through a unique mechanism involving ribosomal frameshifting in response to polyamine concentrations, ensuring the production of functional antizyme only when polyamine levels are high. Structurally, OAZ1 binds to ODC, targeting it for proteasomal degradation, and its interaction with ODC is influenced by specific amino acid residues, as demonstrated by mutagenesis studies. In terms of disease relevance, OAZ1 has been shown to inhibit proliferation and induce differentiation in certain cancer cells, such as oral cancer, suggesting a potential tumor-suppressive role by limiting excessive polyamine-driven cell growth.
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技术参数
- 靶点基因名
- OAZ1
- 基因别名
- OAZ
- 蛋白别名
- ornithine decarboxylase antizyme 1; OAZ1
- UniProt
- P54368
- 物种
- Human
产品详情
- 靶点名称
- OAZ1
- 蛋白名称
- ornithine decarboxylase antizyme 1
- 蛋白别名
- Ornithine decarboxylase antizyme 1; AZ1; ODC-Az
- 靶点基因名
- OAZ1
- 基因别名
- OAZ
- UniProt
- P54368
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ornithine decarboxylase antizyme 1 (OAZ1) is a regulatory protein that plays a crucial role in controlling intracellular polyamine levels by negatively regulating ornithine decarboxylase (ODC) activity and polyamine uptake, thereby influencing cell growth and proliferation. OAZ1 is widely expressed in human tissues and is part of the antizyme family, which modulates polyamine biosynthesis through a unique mechanism involving ribosomal frameshifting in response to polyamine concentrations, ensuring the production of functional antizyme only when polyamine levels are high. Structurally, OAZ1 binds to ODC, targeting it for proteasomal degradation, and its interaction with ODC is influenced by specific amino acid residues, as demonstrated by mutagenesis studies. In terms of disease relevance, OAZ1 has been shown to inhibit proliferation and induce differentiation in certain cancer cells, such as oral cancer, suggesting a potential tumor-suppressive role by limiting excessive polyamine-driven cell growth.