人 NXPH3 抗体对
01AB01263
Neurexophilin 3 (NXPH3) is a secreted neuronal glycoprotein that functions as a specific ligand for presynaptic α-neurexins, forming a tight extracellular complex essential for efficient neurotransmitter release. Structurally, NXPH3 contains a signal peptide and mature peptide region and is localized mainly in select neuronal populations such as subplate-derived neurons in cortical layer 6b, granule cells in the vestibulocerebellum, and Cajal-Retzius cells during development. Its expression pattern suggests a modulatory role in synaptic function rather than a universal cofactor for α-neurexins. Functional studies in knockout mice revealed that loss of NXPH3 leads to sensory processing deficits and impaired motor coordination without gross anatomical brain defects, indicating its importance in specific neuronal circuits involved in sensorimotor gating. Clinically, mutations or dysregulation of NXPH3 have been linked to neurodevelopmental disorders such as lissencephaly with complex brainstem malformations and Sjogren-Larsson syndrome.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- NXPH3
- 基因别名
- KIAA1159; NPH3
- 蛋白别名
- neurexophilin 3; NXPH3
- UniProt
- O95157
- 物种
- Human
产品详情
- 靶点名称
- NXPH3
- 蛋白名称
- neurexophilin 3
- 蛋白别名
- Neurexophilin-3
- 靶点基因名
- NXPH3
- 基因别名
- KIAA1159; NPH3
- UniProt
- O95157
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neurexophilin 3 (NXPH3) is a secreted neuronal glycoprotein that functions as a specific ligand for presynaptic α-neurexins, forming a tight extracellular complex essential for efficient neurotransmitter release. Structurally, NXPH3 contains a signal peptide and mature peptide region and is localized mainly in select neuronal populations such as subplate-derived neurons in cortical layer 6b, granule cells in the vestibulocerebellum, and Cajal-Retzius cells during development. Its expression pattern suggests a modulatory role in synaptic function rather than a universal cofactor for α-neurexins. Functional studies in knockout mice revealed that loss of NXPH3 leads to sensory processing deficits and impaired motor coordination without gross anatomical brain defects, indicating its importance in specific neuronal circuits involved in sensorimotor gating. Clinically, mutations or dysregulation of NXPH3 have been linked to neurodevelopmental disorders such as lissencephaly with complex brainstem malformations and Sjogren-Larsson syndrome.