人 NUP214 抗体对
01AB03152
Nucleoporin 214 (NUP214) is a large nucleoporin localized to the cytoplasmic filaments of the nuclear pore complex. Containing extensive FG-repeats, it serves as a primary docking site for the export receptor CRM1, facilitating the nuclear export of proteins and mRNA. NUP214 is essential for efficient nucleocytoplasmic transport. In hematologic malignancies, the gene is frequently involved in chromosomal translocations, such as the DEK-NUP214 fusion in acute myeloid leukemia. These fusions disrupt normal transport dynamics and gene regulation, driving leukemogenesis and correlating with poor clinical prognosis.
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技术参数
- 靶点基因名
- NUP214
- 基因别名
- CAIN; CAN; KIAA0023
- 蛋白别名
- nucleoporin 214; NUP214
- UniProt
- P35658
- 物种
- Human
产品详情
- 靶点名称
- NUP214
- 蛋白名称
- nucleoporin 214
- 蛋白别名
- Nuclear pore complex protein Nup214; 214 kDa nucleoporin; Nucleoporin Nup214; Protein CAN
- 靶点基因名
- NUP214
- 基因别名
- CAIN; CAN; KIAA0023
- UniProt
- P35658
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Nucleoporin 214 (NUP214) is a large nucleoporin localized to the cytoplasmic filaments of the nuclear pore complex. Containing extensive FG-repeats, it serves as a primary docking site for the export receptor CRM1, facilitating the nuclear export of proteins and mRNA. NUP214 is essential for efficient nucleocytoplasmic transport. In hematologic malignancies, the gene is frequently involved in chromosomal translocations, such as the DEK-NUP214 fusion in acute myeloid leukemia. These fusions disrupt normal transport dynamics and gene regulation, driving leukemogenesis and correlating with poor clinical prognosis.