人 NUCB1 抗体对
01AB00551
Nucleobindin 1 (NUCB1), also known as calnuc, is a calcium-binding protein encoded by the NUCB1 gene, primarily involved in Golgi calcium homeostasis and signal transduction. It exists as a dimer and binds two calcium ions, which induces conformational changes that affect its interactions with G proteins, specifically inhibiting the GDP release from Gα_i1 proteins. This function positions NUCB1 as a calcium-dependent guanine nucleotide dissociation inhibitor (GDI), playing a crucial role in regulating G protein-coupled receptor signaling pathways. Dysregulation of NUCB1 has been linked to various diseases, including Chromosome 16P11.2 Duplication Syndrome and pancreatic ductal adenocarcinoma (PDAC), where reduced levels correlate with poor prognosis and increased cancer cell proliferation.
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技术参数
- 靶点基因名
- NUCB1
- 基因别名
- NUC
- 蛋白别名
- nucleobindin 1; NUCB1
- UniProt
- Q02818
- 物种
- Human
产品详情
- 靶点名称
- NUCB1
- 蛋白名称
- nucleobindin 1
- 蛋白别名
- Nucleobindin-1; CALNUC
- 靶点基因名
- NUCB1
- 基因别名
- NUC
- UniProt
- Q02818
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Nucleobindin 1 (NUCB1), also known as calnuc, is a calcium-binding protein encoded by the NUCB1 gene, primarily involved in Golgi calcium homeostasis and signal transduction. It exists as a dimer and binds two calcium ions, which induces conformational changes that affect its interactions with G proteins, specifically inhibiting the GDP release from Gα_i1 proteins. This function positions NUCB1 as a calcium-dependent guanine nucleotide dissociation inhibitor (GDI), playing a crucial role in regulating G protein-coupled receptor signaling pathways. Dysregulation of NUCB1 has been linked to various diseases, including Chromosome 16P11.2 Duplication Syndrome and pancreatic ductal adenocarcinoma (PDAC), where reduced levels correlate with poor prognosis and increased cancer cell proliferation.