人 NSF 抗体对
01AB02228
N-ethylmaleimide sensitive factor, vesicle fusing ATPase (NSF) is a ubiquitously expressed cytosolic AAA+ ATPase that functions as a homohexamer to drive intracellular membrane trafficking. NSF plays a fundamental role in the vesicle fusion cycle by binding to SNARE complexes via soluble NSF attachment proteins (SNAPs). Utilizing energy from ATP hydrolysis, it mechanically disassembles post-fusion cis-SNARE complexes, thereby recycling individual SNARE proteins for subsequent rounds of fusion. This chaperone-like activity is essential for nearly all trafficking events, including synaptic vesicle exocytosis and the transport of AMPA receptors. Consequently, NSF is a critical determinant of neurotransmitter release and synaptic plasticity. Clinically, dysfunction in NSF-mediated SNARE disassembly is implicated in various neurological disorders characterized by defects in synaptic transmission and cognitive function.
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技术参数
- 靶点基因名
- NSF
- 蛋白别名
- N-ethylmaleimide sensitive factor, vesicle fusing ATPase; NSF
- UniProt
- P46459
- 物种
- Human
产品详情
- 靶点名称
- NSF
- 蛋白名称
- N-ethylmaleimide sensitive factor, vesicle fusing ATPase
- 蛋白别名
- Vesicle-fusing ATPase; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; Vesicular-fusion protein NSF
- 靶点基因名
- NSF
- UniProt
- P46459
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
N-ethylmaleimide sensitive factor, vesicle fusing ATPase (NSF) is a ubiquitously expressed cytosolic AAA+ ATPase that functions as a homohexamer to drive intracellular membrane trafficking. NSF plays a fundamental role in the vesicle fusion cycle by binding to SNARE complexes via soluble NSF attachment proteins (SNAPs). Utilizing energy from ATP hydrolysis, it mechanically disassembles post-fusion cis-SNARE complexes, thereby recycling individual SNARE proteins for subsequent rounds of fusion. This chaperone-like activity is essential for nearly all trafficking events, including synaptic vesicle exocytosis and the transport of AMPA receptors. Consequently, NSF is a critical determinant of neurotransmitter release and synaptic plasticity. Clinically, dysfunction in NSF-mediated SNARE disassembly is implicated in various neurological disorders characterized by defects in synaptic transmission and cognitive function.