抗人 NR4A1 抗体对
01AB01533
Nuclear receptor subfamily 4 group A member 1 (NR4A1) is an orphan nuclear receptor that functions as a transcription factor. It binds to the NGFI-B response element (NBRE) and regulates gene expression involved in cell proliferation, apoptosis, and inflammation. NR4A1 can be induced by various stimuli, including growth factors and stress, and plays roles in energy homeostasis, immune regulation, and vascular response to injury. The protein can translocate from the nucleus to mitochondria, triggering apoptosis. In macrophages, NR4A1 regulates metabolic adaptations during inflammation by repressing genes involved in the citric acid cycle. NR4A1 is associated with diseases such as pseudohypoaldosteronism and pyomyositis. In cancer, NR4A1 has been implicated in colorectal cancer progression, where its depletion inhibits cancer advancement by promoting necroptosis via the RIG-I-like receptor pathway.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- NR4A1
- 基因别名
- GFRP1; HMR; NAK1
- 蛋白别名
- nuclear receptor subfamily 4 group A member 1; NR4A1
- UniProt
- P22736
- 物种
- Human
产品详情
- 靶点名称
- NR4A1
- 蛋白名称
- nuclear receptor subfamily 4 group A member 1
- 蛋白别名
- Nuclear receptor subfamily 4immunitygroup A member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3
- 靶点基因名
- NR4A1
- 基因别名
- GFRP1; HMR; NAK1
- UniProt
- P22736
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Nuclear receptor subfamily 4 group A member 1 (NR4A1) is an orphan nuclear receptor that functions as a transcription factor. It binds to the NGFI-B response element (NBRE) and regulates gene expression involved in cell proliferation, apoptosis, and inflammation. NR4A1 can be induced by various stimuli, including growth factors and stress, and plays roles in energy homeostasis, immune regulation, and vascular response to injury. The protein can translocate from the nucleus to mitochondria, triggering apoptosis. In macrophages, NR4A1 regulates metabolic adaptations during inflammation by repressing genes involved in the citric acid cycle. NR4A1 is associated with diseases such as pseudohypoaldosteronism and pyomyositis. In cancer, NR4A1 has been implicated in colorectal cancer progression, where its depletion inhibits cancer advancement by promoting necroptosis via the RIG-I-like receptor pathway.