人 NPTX2 抗体对
01AB02222
Neuronal pentraxin 2 (NPTX2), also known as NARP, is a synaptic protein encoded by the NPTX2 gene and is part of the neuronal pentraxin family, which is structurally related to C-reactive protein. NPTX2 functions as an immediate-early gene product that plays a pivotal role in excitatory synapse formation and synaptic plasticity by clustering AMPA-type glutamate receptors at established synapses. It is secreted in response to neuronal activity and can aggregate excitatory receptors, facilitating long-term neuronal plasticity and potentially modifying cellular properties underlying these processes. NPTX2 forms complexes with other pentraxins, such as NPTX1 and neuronal pentraxin receptor (NPR), and is involved in calcium-dependent binding and receptor internalization, which may protect against excitotoxicity. Clinically, NPTX2 is highly upregulated in Parkinson’s disease (PD) tissues, particularly in the substantia nigra, and is a novel component of Lewy bodies and Lewy neurites, suggesting a role in PD pathology and dopaminergic neuron death.
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技术参数
- 靶点基因名
- NPTX2
- 蛋白别名
- neuronal pentraxin 2; NPTX2
- UniProt
- P47972
- 物种
- Human
产品详情
- 靶点名称
- NPTX2
- 蛋白名称
- neuronal pentraxin 2
- 蛋白别名
- Neuronal pentraxin-2; NP2; Neuronal pentraxin II; NP-II
- 靶点基因名
- NPTX2
- UniProt
- P47972
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neuronal pentraxin 2 (NPTX2), also known as NARP, is a synaptic protein encoded by the NPTX2 gene and is part of the neuronal pentraxin family, which is structurally related to C-reactive protein. NPTX2 functions as an immediate-early gene product that plays a pivotal role in excitatory synapse formation and synaptic plasticity by clustering AMPA-type glutamate receptors at established synapses. It is secreted in response to neuronal activity and can aggregate excitatory receptors, facilitating long-term neuronal plasticity and potentially modifying cellular properties underlying these processes. NPTX2 forms complexes with other pentraxins, such as NPTX1 and neuronal pentraxin receptor (NPR), and is involved in calcium-dependent binding and receptor internalization, which may protect against excitotoxicity. Clinically, NPTX2 is highly upregulated in Parkinson’s disease (PD) tissues, particularly in the substantia nigra, and is a novel component of Lewy bodies and Lewy neurites, suggesting a role in PD pathology and dopaminergic neuron death.