人 NPM1 抗体对
01AB00319
Nucleophosmin 1 (NPM1) is a multifunctional protein primarily localized in the nucleolus but capable of shuttling between the nucleus and cytoplasm. It plays critical roles in ribosome biogenesis, histone chaperoning, and DNA damage repair. NPM1 has a modular structure with a folded N-terminal domain, an intrinsically disordered region, and a C-terminal nucleotide-binding domain, which enables its oligomerization and interaction with various proteins and nucleic acids. Its chaperone activity helps prevent protein aggregation, particularly in the densely packed nucleolus, and it is involved in the regulation of pre-ribosome RNA transcription and maturation. Mutations in NPM1 are frequently associated with acute myeloid leukemia and other cancers.
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技术参数
- 靶点基因名
- NPM1
- 基因别名
- NPM
- 蛋白别名
- nucleophosmin 1; NPM1
- UniProt
- P06748
- 物种
- Human
产品详情
- 靶点名称
- NPM1
- 蛋白名称
- nucleophosmin 1
- 蛋白别名
- Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin
- 靶点基因名
- NPM1
- 基因别名
- NPM
- UniProt
- P06748
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Nucleophosmin 1 (NPM1) is a multifunctional protein primarily localized in the nucleolus but capable of shuttling between the nucleus and cytoplasm. It plays critical roles in ribosome biogenesis, histone chaperoning, and DNA damage repair. NPM1 has a modular structure with a folded N-terminal domain, an intrinsically disordered region, and a C-terminal nucleotide-binding domain, which enables its oligomerization and interaction with various proteins and nucleic acids. Its chaperone activity helps prevent protein aggregation, particularly in the densely packed nucleolus, and it is involved in the regulation of pre-ribosome RNA transcription and maturation. Mutations in NPM1 are frequently associated with acute myeloid leukemia and other cancers.