人 NOXA2 抗体对
01AB01248
Neutrophil cytosolic factor 2 (NCF2) is a 67-kilodalton cytosolic protein encoded by the NCF2 gene located on chromosome 1 in humans. It functions as a critical subunit of the multi-protein NADPH oxidase complex found in neutrophils, mediating the transfer of electrons from cytosolic NADPH to molecular oxygen to produce superoxide anions. This process generates a respiratory burst that delivers superoxide to the lumen of neutrophil phagosomes, playing an essential role in the immune response against pathogens. Mutations in NCF2 can result in chronic granulomatous disease, characterized by impaired neutrophil function and recurrent infections. Additionally, certain genetic variations in NCF2 have been associated with increased risk of systemic lupus erythematosus, an autoimmune disorder. These variants are thought to impair NADPH oxidase function, reducing reactive oxygen species production and triggering an overactive immune response that may attack the body's own tissues and organs.
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技术参数
- 靶点基因名
- NCF2
- 基因别名
- NOXA2; P67PHOX
- 蛋白别名
- neutrophil cytosolic factor 2; NOXA2
- UniProt
- P19878
- 物种
- Human
产品详情
- 靶点名称
- NOXA2
- 蛋白名称
- neutrophil cytosolic factor 2
- 蛋白别名
- Neutrophil cytosol factor 2; NCF-2; 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; Neutrophil NADPH oxidase factor 2; p67-phox
- 靶点基因名
- NCF2
- 基因别名
- NOXA2; P67PHOX
- UniProt
- P19878
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neutrophil cytosolic factor 2 (NCF2) is a 67-kilodalton cytosolic protein encoded by the NCF2 gene located on chromosome 1 in humans. It functions as a critical subunit of the multi-protein NADPH oxidase complex found in neutrophils, mediating the transfer of electrons from cytosolic NADPH to molecular oxygen to produce superoxide anions. This process generates a respiratory burst that delivers superoxide to the lumen of neutrophil phagosomes, playing an essential role in the immune response against pathogens. Mutations in NCF2 can result in chronic granulomatous disease, characterized by impaired neutrophil function and recurrent infections. Additionally, certain genetic variations in NCF2 have been associated with increased risk of systemic lupus erythematosus, an autoimmune disorder. These variants are thought to impair NADPH oxidase function, reducing reactive oxygen species production and triggering an overactive immune response that may attack the body's own tissues and organs.