人 NOS3 抗体对
01AB04107
Nitric oxide synthase 3 (NOS3), also known as endothelial nitric oxide synthase (eNOS), is an enzyme that catalyzes the production of nitric oxide (NO) from L-arginine in endothelial cells. This protein plays a crucial role in regulating vascular tone, promoting vasodilation, and maintaining blood flow through a cyclic guanosine monophosphate (cGMP)-mediated signaling pathway. NOS3 is a dimeric enzyme composed of two identical subunits, each containing a reductase domain and an oxidase domain, which require calcium and calmodulin for activation. Dysregulation of NOS3 is associated with several cardiovascular diseases, including hypertension, atherosclerosis, and coronary artery disease, where impaired NO production can lead to endothelial dysfunction and increased vascular resistance. Genetic variations in the NOS3 gene have also been linked to susceptibility to conditions such as stroke and ischemic heart disease.
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技术参数
- 靶点基因名
- NOS3
- 蛋白别名
- nitric oxide synthase 3; NOS3
- UniProt
- P29474
- 物种
- Human
产品详情
- 靶点名称
- NOS3
- 蛋白名称
- nitric oxide synthase 3
- 蛋白别名
- Nitric oxide synthase 3; Constitutive NOS; cNOS; EC-NOS; NOS type III; NOSIII; Nitric oxide synthase; endothelial; Endothelial NOS; eNOS
- 靶点基因名
- NOS3
- UniProt
- P29474
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Nitric oxide synthase 3 (NOS3), also known as endothelial nitric oxide synthase (eNOS), is an enzyme that catalyzes the production of nitric oxide (NO) from L-arginine in endothelial cells. This protein plays a crucial role in regulating vascular tone, promoting vasodilation, and maintaining blood flow through a cyclic guanosine monophosphate (cGMP)-mediated signaling pathway. NOS3 is a dimeric enzyme composed of two identical subunits, each containing a reductase domain and an oxidase domain, which require calcium and calmodulin for activation. Dysregulation of NOS3 is associated with several cardiovascular diseases, including hypertension, atherosclerosis, and coronary artery disease, where impaired NO production can lead to endothelial dysfunction and increased vascular resistance. Genetic variations in the NOS3 gene have also been linked to susceptibility to conditions such as stroke and ischemic heart disease.