人 NOP2 抗体对
01AB02861
NOP2 nucleolar protein (NOP2) is a highly conserved S-adenosyl-L-methionine-dependent RNA methyltransferase that catalyzes the C5-methylation of cytosine 4447 in 28S rRNA. This modification is essential for efficient pre-rRNA processing and the biogenesis of the 60S ribosomal subunit. NOP2 also regulates ribosome assembly through non-catalytic interactions with box C/D snoRNAs, promoting the recruitment of U3 and U8 snoRNAs to pre-90S particles. Beyond its role in ribosome biogenesis, NOP2 is involved in the positive regulation of cell proliferation and p53-mediated signaling. Clinically, NOP2 is overexpressed in various malignancies, including high-grade serous ovarian cancer, where it acts as an oncogenic factor. It promotes tumor cell proliferation, migration, and invasion through m5C-dependent regulation of the cAMP pathway, and its high expression levels are significantly correlated with poor patient prognosis.
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技术参数
- 靶点基因名
- NOP2
- 基因别名
- NOL1; NSUN1
- 蛋白别名
- NOP2 nucleolar protein; NOP2
- UniProt
- P46087
- 物种
- Human
产品详情
- 靶点名称
- NOP2
- 蛋白名称
- NOP2 nucleolar protein
- 蛋白别名
- 28S rRNA; cytosine(4447)-C(5))-methyltransferase; Nucleolar protein 1; Nucleolar protein 2 homolog; Proliferating-cell nucleolar antigen p120; Proliferation-associated nucleolar protein p120
- 靶点基因名
- NOP2
- 基因别名
- NOL1; NSUN1
- UniProt
- P46087
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
NOP2 nucleolar protein (NOP2) is a highly conserved S-adenosyl-L-methionine-dependent RNA methyltransferase that catalyzes the C5-methylation of cytosine 4447 in 28S rRNA. This modification is essential for efficient pre-rRNA processing and the biogenesis of the 60S ribosomal subunit. NOP2 also regulates ribosome assembly through non-catalytic interactions with box C/D snoRNAs, promoting the recruitment of U3 and U8 snoRNAs to pre-90S particles. Beyond its role in ribosome biogenesis, NOP2 is involved in the positive regulation of cell proliferation and p53-mediated signaling. Clinically, NOP2 is overexpressed in various malignancies, including high-grade serous ovarian cancer, where it acts as an oncogenic factor. It promotes tumor cell proliferation, migration, and invasion through m5C-dependent regulation of the cAMP pathway, and its high expression levels are significantly correlated with poor patient prognosis.