人 NOMO1 抗体对
01AB01782
NODAL modulator 1 (NOMO1) is a type I transmembrane glycoprotein localized to the endoplasmic reticulum (ER) lumen. It serves as a core component of the multi-pass translocon (MPT/BOS) complex, which facilitates the insertion of multi-pass membrane proteins following their initial engagement by the SEC61 translocon. NOMO1 contains conserved immunoglobulin-like domains and forms a rod-shaped, force-bearing structure that helps maintain ER membrane spacing and sheet morphology. As one of three highly similar paralogs, it participates in protein complexes that modulate Nodal signaling during vertebrate development. Clinically, deletions of the NOMO1 gene are recurrently observed in colorectal cancer, particularly in microsatellite-stable, early-onset tumors, where they serve as a molecular marker rather than a primary driver of disease.
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技术参数
- 靶点基因名
- NOMO1
- 基因别名
- PM5
- 蛋白别名
- NODAL modulator 1; NOMO1
- UniProt
- Q15155
- 物种
- Human
产品详情
- 靶点名称
- NOMO1
- 蛋白名称
- NODAL modulator 1
- 蛋白别名
- BOS complex subunit NOMO1; Nodal modulator 1; pM5 protein
- 靶点基因名
- NOMO1
- 基因别名
- PM5
- UniProt
- Q15155
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
NODAL modulator 1 (NOMO1) is a type I transmembrane glycoprotein localized to the endoplasmic reticulum (ER) lumen. It serves as a core component of the multi-pass translocon (MPT/BOS) complex, which facilitates the insertion of multi-pass membrane proteins following their initial engagement by the SEC61 translocon. NOMO1 contains conserved immunoglobulin-like domains and forms a rod-shaped, force-bearing structure that helps maintain ER membrane spacing and sheet morphology. As one of three highly similar paralogs, it participates in protein complexes that modulate Nodal signaling during vertebrate development. Clinically, deletions of the NOMO1 gene are recurrently observed in colorectal cancer, particularly in microsatellite-stable, early-onset tumors, where they serve as a molecular marker rather than a primary driver of disease.