人 NMNAT1 抗体对
01AB01887
Nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) is a nuclear enzyme that catalyzes a crucial step in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), converting nicotinamide mononucleotide (NMN) and ATP into NAD+ and pyrophosphate, a reaction essential for cellular metabolism and energy homeostasis. NMNAT1 exhibits transferase and nucleotidyltransferase activity, binding nucleotides and ATP, and is strongly inhibited by certain polyphenols such as gallotannin. The protein is highly conserved and plays a protective role in neuronal cells, notably delaying axonal degeneration after injury, although its axon-protective function is less robust than that of the related Wld(S) protein. Clinically, mutations in NMNAT1 are linked to Leber's congenital amaurosis type 9 (LCA9), a severe inherited retinal dystrophy that leads to early-onset vision loss. Additionally, NMNAT1 expression declines with age in several tissues, potentially impacting NAD+ metabolism and age-related cellular functions.
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技术参数
- 靶点基因名
- NMNAT1
- 基因别名
- NMNAT
- 蛋白别名
- nicotinamide nucleotide adenylyltransferase 1; NMNAT1
- UniProt
- Q9HAN9
- 物种
- Human
产品详情
- 靶点名称
- NMNAT1
- 蛋白名称
- nicotinamide nucleotide adenylyltransferase 1
- 蛋白别名
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1
- 靶点基因名
- NMNAT1
- 基因别名
- NMNAT
- UniProt
- Q9HAN9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) is a nuclear enzyme that catalyzes a crucial step in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), converting nicotinamide mononucleotide (NMN) and ATP into NAD+ and pyrophosphate, a reaction essential for cellular metabolism and energy homeostasis. NMNAT1 exhibits transferase and nucleotidyltransferase activity, binding nucleotides and ATP, and is strongly inhibited by certain polyphenols such as gallotannin. The protein is highly conserved and plays a protective role in neuronal cells, notably delaying axonal degeneration after injury, although its axon-protective function is less robust than that of the related Wld(S) protein. Clinically, mutations in NMNAT1 are linked to Leber's congenital amaurosis type 9 (LCA9), a severe inherited retinal dystrophy that leads to early-onset vision loss. Additionally, NMNAT1 expression declines with age in several tissues, potentially impacting NAD+ metabolism and age-related cellular functions.