人 NINJ2 抗体对
01AB01777
Ninjurin 2 (NINJ2) is a double-pass cell-surface adhesion protein that mediates homophilic interactions to promote neurite and axonal outgrowth. It is significantly upregulated in Schwann cells following nerve injury, indicating a primary role in nerve regeneration. Beyond the nervous system, NINJ2 is involved in modulating cell growth and senescence through a feedback loop with p53, where it is induced by DNA damage and subsequently represses p53 translation. Clinically, NINJ2 is overexpressed in colorectal cancer, where it functions as an oncogenic adaptor for multiple receptor tyrosine kinases. This interaction activates Akt/Erk signaling pathways, driving tumor cell proliferation, survival, and migration, thereby positioning NINJ2 as a potential target in oncological research.
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技术参数
- 靶点基因名
- NINJ2
- 蛋白别名
- ninjurin 2; NINJ2
- UniProt
- Q9NZG7
- 物种
- Human
产品详情
- 靶点名称
- NINJ2
- 蛋白名称
- ninjurin 2
- 蛋白别名
- Ninjurin-2; Nerve injury-induced protein 2
- 靶点基因名
- NINJ2
- UniProt
- Q9NZG7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ninjurin 2 (NINJ2) is a double-pass cell-surface adhesion protein that mediates homophilic interactions to promote neurite and axonal outgrowth. It is significantly upregulated in Schwann cells following nerve injury, indicating a primary role in nerve regeneration. Beyond the nervous system, NINJ2 is involved in modulating cell growth and senescence through a feedback loop with p53, where it is induced by DNA damage and subsequently represses p53 translation. Clinically, NINJ2 is overexpressed in colorectal cancer, where it functions as an oncogenic adaptor for multiple receptor tyrosine kinases. This interaction activates Akt/Erk signaling pathways, driving tumor cell proliferation, survival, and migration, thereby positioning NINJ2 as a potential target in oncological research.