人 NFKBIE 抗体对
01AB00545
NFKB inhibitor epsilon (NFKBIE), or Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, is a protein that inhibits the NF-κB transcription factor complex by trapping it in the cytoplasm. This protein is encoded by the NFKBIE gene located on chromosome 6 in humans. NFKBIE binds to components of NF-κB, preventing it from activating genes in the nucleus. The NF-κB complex is crucial for various cellular processes, including immune responses and inflammation. NFKBIE's expression is up-regulated following NF-κB activation and during myelopoiesis, indicating its role in regulating NF-κB activity. NFKBIE interacts with NFKB2, RELA, NFKB1, and REL, further emphasizing its role in modulating NF-κB signaling. The function of NFKBIE in regulating NF-κB activity suggests its potential involvement in conditions related to immune dysregulation and inflammation.
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技术参数
- 靶点基因名
- NFKBIE
- 基因别名
- IKBE
- 蛋白别名
- NFKB inhibitor epsilon; NFKBIE
- UniProt
- O00221
- 物种
- Human
产品详情
- 靶点名称
- NFKBIE
- 蛋白名称
- NFKB inhibitor epsilon
- 蛋白别名
- NF-kappa-B inhibitor epsilon; NF-kappa-BIE; I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon
- 靶点基因名
- NFKBIE
- 基因别名
- IKBE
- UniProt
- O00221
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
NFKB inhibitor epsilon (NFKBIE), or Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, is a protein that inhibits the NF-κB transcription factor complex by trapping it in the cytoplasm. This protein is encoded by the NFKBIE gene located on chromosome 6 in humans. NFKBIE binds to components of NF-κB, preventing it from activating genes in the nucleus. The NF-κB complex is crucial for various cellular processes, including immune responses and inflammation. NFKBIE's expression is up-regulated following NF-κB activation and during myelopoiesis, indicating its role in regulating NF-κB activity. NFKBIE interacts with NFKB2, RELA, NFKB1, and REL, further emphasizing its role in modulating NF-κB signaling. The function of NFKBIE in regulating NF-κB activity suggests its potential involvement in conditions related to immune dysregulation and inflammation.