人 Neurocan 抗体对
01AB01769
Neurocan (Neurocan) is a secreted extracellular matrix chondroitin sulfate proteoglycan of the lectican family, primarily expressed in the developing and remodeling central nervous system. It possesses a characteristic structure including an N-terminal hyaluronan-binding domain and a C-terminal lectin-like domain, allowing it to interact with hyaluronan, tenascin-C, and various cell-adhesion molecules like NCAM and L1. Through these interactions, neurocan modulates neuronal adhesion, cell migration, and neurite outgrowth. It is notably upregulated following nervous system injury, where it acts as a potent inhibitor of axon regeneration. In a clinical context, neurocan overexpression is associated with increased malignancy in neuroblastoma, where it promotes tumor sphere formation, stemness-associated gene expression, and the maintenance of the cancer stem cell niche.
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技术参数
- 靶点基因名
- NCAN
- 基因别名
- CSPG3; NEUR
- 蛋白别名
- neurocan; Neurocan
- UniProt
- O14594
- 物种
- Human
产品详情
- 靶点名称
- Neurocan
- 蛋白名称
- neurocan
- 蛋白别名
- Neurocan core protein; Chondroitin sulfate proteoglycan 3
- 靶点基因名
- NCAN
- 基因别名
- CSPG3; NEUR
- UniProt
- O14594
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neurocan (Neurocan) is a secreted extracellular matrix chondroitin sulfate proteoglycan of the lectican family, primarily expressed in the developing and remodeling central nervous system. It possesses a characteristic structure including an N-terminal hyaluronan-binding domain and a C-terminal lectin-like domain, allowing it to interact with hyaluronan, tenascin-C, and various cell-adhesion molecules like NCAM and L1. Through these interactions, neurocan modulates neuronal adhesion, cell migration, and neurite outgrowth. It is notably upregulated following nervous system injury, where it acts as a potent inhibitor of axon regeneration. In a clinical context, neurocan overexpression is associated with increased malignancy in neuroblastoma, where it promotes tumor sphere formation, stemness-associated gene expression, and the maintenance of the cancer stem cell niche.