抗人 NELL1 抗体对
01AB03833
Neural EGFL like 1 (NELL1) is a secreted protein characterized by its epidermal growth factor (EGF)-like repeats, playing a pivotal role in cellular growth and differentiation, particularly in osteogenesis. Functionally, NELL1 interacts with integrin β1, activating the Wnt/β-catenin signaling pathway, which promotes osteoblast differentiation and inhibits osteoclast activity. NELL1 is crucial for skeletal ossification, as its overexpression can lead to craniosynostosis, a condition where skull bones fuse prematurely, while its deficiency is linked to age-related osteoporosis, marked by decreased bone density and increased fragility. Beyond skeletal implications, NELL1 has been identified as a target antigen in membranous nephropathy (MN).
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技术参数
- 靶点基因名
- NELL1
- 基因别名
- NRP1
- 蛋白别名
- neural EGFL like 1; NELL1
- UniProt
- Q92832
- 物种
- Human
产品详情
- 靶点名称
- NELL1
- 蛋白名称
- neural EGFL like 1
- 蛋白别名
- Protein kinase C-binding protein NELL1; NEL-like protein 1; Nel-related protein 1
- 靶点基因名
- NELL1
- 基因别名
- NRP1
- UniProt
- Q92832
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neural EGFL like 1 (NELL1) is a secreted protein characterized by its epidermal growth factor (EGF)-like repeats, playing a pivotal role in cellular growth and differentiation, particularly in osteogenesis. Functionally, NELL1 interacts with integrin β1, activating the Wnt/β-catenin signaling pathway, which promotes osteoblast differentiation and inhibits osteoclast activity. NELL1 is crucial for skeletal ossification, as its overexpression can lead to craniosynostosis, a condition where skull bones fuse prematurely, while its deficiency is linked to age-related osteoporosis, marked by decreased bone density and increased fragility. Beyond skeletal implications, NELL1 has been identified as a target antigen in membranous nephropathy (MN).