人 NELFCD 抗体对
01AB02089
Negative elongation factor complex member C/D (NELFCD) is an essential subunit of the four-protein NELF complex, which also includes NELF-A, NELF-B, and NELF-E. This complex cooperates with the DRB-sensitivity inducing factor (DSIF) to induce promoter-proximal pausing of RNA polymerase II, thereby acting as a negative regulator of transcriptional elongation. NELFCD exists in at least two isoforms generated by alternative translation initiation, both of which integrate into the NELF complex within the nucleus. The transcriptional pausing mediated by NELFCD can be relieved by P-TEFb-dependent phosphorylation, allowing for highly regulated gene expression. Additionally, NELFCD is involved in HIV-1 transcription, where the NELF complex contributes to viral latency by maintaining Pol II in a paused state. Its role in fine-tuning the timing and efficiency of transcript production is fundamental to cellular gene regulation and response to external stimuli.
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技术参数
- 靶点基因名
- NELFCD
- 基因别名
- NELFD; TH1; TH1L
- 蛋白别名
- negative elongation factor complex member C/D; NELFCD
- UniProt
- Q8IXH7
- 物种
- Human
产品详情
- 靶点名称
- NELFCD
- 蛋白名称
- negative elongation factor complex member C/D
- 蛋白别名
- Negative elongation factor C/D; NELF-C/D; TH1-like protein
- 靶点基因名
- NELFCD
- 基因别名
- NELFD; TH1; TH1L
- UniProt
- Q8IXH7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Negative elongation factor complex member C/D (NELFCD) is an essential subunit of the four-protein NELF complex, which also includes NELF-A, NELF-B, and NELF-E. This complex cooperates with the DRB-sensitivity inducing factor (DSIF) to induce promoter-proximal pausing of RNA polymerase II, thereby acting as a negative regulator of transcriptional elongation. NELFCD exists in at least two isoforms generated by alternative translation initiation, both of which integrate into the NELF complex within the nucleus. The transcriptional pausing mediated by NELFCD can be relieved by P-TEFb-dependent phosphorylation, allowing for highly regulated gene expression. Additionally, NELFCD is involved in HIV-1 transcription, where the NELF complex contributes to viral latency by maintaining Pol II in a paused state. Its role in fine-tuning the timing and efficiency of transcript production is fundamental to cellular gene regulation and response to external stimuli.