人 NEDD9 抗体对
01AB00316
Neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) is a non-catalytic scaffolding protein that plays a crucial role in regulating multiple cellular processes, including cell migration, invasion, and metastasis in various cancers. It contains several functional domains, including an N-terminal SH3 domain, a substrate domain, a serine-rich region, and a C-terminal domain with a focal adhesion targeting (FAT) function and a SRC-binding motif. NEDD9 is involved in the signaling crosstalk between integrins and receptor tyrosine kinases, such as EGFR, and its overexpression has been associated with aggressive tumor behavior and poor prognosis in non-small cell lung cancer (NSCLC), breast cancer, melanoma, and other malignancies. The protein is subject to post-translational modifications, including phosphorylation and proteasomal degradation, which influence its scaffolding activity and localization.
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技术参数
- 靶点基因名
- NEDD9
- 基因别名
- CASL
- 蛋白别名
- neural precursor cell expressed, developmentally down-regulated 9; NEDD9
- UniProt
- Q14511
- 物种
- Human
产品详情
- 靶点名称
- NEDD9
- 蛋白名称
- neural precursor cell expressed, developmentally down-regulated 9
- 蛋白别名
- Enhancer of filamentation 1; hEF1; CRK-associated substrate-related protein; CAS-L; CasL; Cas scaffolding protein family member 2; CASS2; Neural precursor cell expressed developmentally down-regulated protein 9; NEDD-9; Renal carcinoma antigen NY-REN-12; p105) [Cleaved into: Enhancer of filamentation 1 p55]
- 靶点基因名
- NEDD9
- 基因别名
- CASL
- UniProt
- Q14511
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) is a non-catalytic scaffolding protein that plays a crucial role in regulating multiple cellular processes, including cell migration, invasion, and metastasis in various cancers. It contains several functional domains, including an N-terminal SH3 domain, a substrate domain, a serine-rich region, and a C-terminal domain with a focal adhesion targeting (FAT) function and a SRC-binding motif. NEDD9 is involved in the signaling crosstalk between integrins and receptor tyrosine kinases, such as EGFR, and its overexpression has been associated with aggressive tumor behavior and poor prognosis in non-small cell lung cancer (NSCLC), breast cancer, melanoma, and other malignancies. The protein is subject to post-translational modifications, including phosphorylation and proteasomal degradation, which influence its scaffolding activity and localization.