人 NDUFA7 抗体对
01AB03279
NADH:ubiquinone oxidoreductase subunit A7 (NDUFA7) is a small, 12.5 kDa protein encoded by the NDUFA7 gene on chromosome 19, functioning as an accessory subunit of mitochondrial Complex I, the first and largest enzyme complex of the electron transport chain located in the inner mitochondrial membrane. NDUFA7 is not directly involved in catalysis but contributes structurally, anchoring the complex within the membrane through its hydrophobic N-terminal domain and interacting with other subunits via its hydrophilic C-terminal region; its secondary structure is primarily alpha-helical with a potential coiled-coil form. Complex I, including NDUFA7, is essential for transferring electrons from NADH to ubiquinone, facilitating ATP production through oxidative phosphorylation. Mutations or dysfunctions in NDUFA7 have been associated with diseases such as Diamond-Blackfan anemia and progressive leukoencephalopathy with ovarian failure, highlighting its clinical relevance in mitochondrial and metabolic disorders.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- NDUFA7
- 蛋白别名
- NADH:ubiquinone oxidoreductase subunit A7; NDUFA7
- UniProt
- O95182
- 物种
- Human
产品详情
- 靶点名称
- NDUFA7
- 蛋白名称
- NADH:ubiquinone oxidoreductase subunit A7
- 蛋白别名
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; Complex I-B14.5a; CI-B14.5a; NADH-ubiquinone oxidoreductase subunit B14.5a
- 靶点基因名
- NDUFA7
- UniProt
- O95182
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
NADH:ubiquinone oxidoreductase subunit A7 (NDUFA7) is a small, 12.5 kDa protein encoded by the NDUFA7 gene on chromosome 19, functioning as an accessory subunit of mitochondrial Complex I, the first and largest enzyme complex of the electron transport chain located in the inner mitochondrial membrane. NDUFA7 is not directly involved in catalysis but contributes structurally, anchoring the complex within the membrane through its hydrophobic N-terminal domain and interacting with other subunits via its hydrophilic C-terminal region; its secondary structure is primarily alpha-helical with a potential coiled-coil form. Complex I, including NDUFA7, is essential for transferring electrons from NADH to ubiquinone, facilitating ATP production through oxidative phosphorylation. Mutations or dysfunctions in NDUFA7 have been associated with diseases such as Diamond-Blackfan anemia and progressive leukoencephalopathy with ovarian failure, highlighting its clinical relevance in mitochondrial and metabolic disorders.