人 NCR1 抗体对
01AB01250
Natural Cytotoxicity Triggering Receptor 1 (NCR1), also known as NKp46, is a protein encoded by the NCR1 gene in humans and is designated as CD335. It is a type I transmembrane receptor belonging to the immunoglobulin superfamily, characterized by two extracellular C2-type Ig-like domains. NCR1 plays a crucial role in activating natural killer (NK) cells to mediate cytotoxicity against tumor and virus-infected cells by associating with ITAM-containing signaling molecules. The gene encoding NCR1 is located on chromosome 19q13.4. In terms of disease, NCR1's role in immune surveillance suggests its potential involvement in cancer, where its function may be exploited for tumor immunotherapy. However, specific disease associations are less detailed compared to its well-characterized role in NK cell activation and cytotoxicity.
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技术参数
- 靶点基因名
- NCR1
- 基因别名
- LY94
- 蛋白别名
- natural cytotoxicity triggering receptor 1; NCR1
- UniProt
- O76036
- 物种
- Human
产品详情
- 靶点名称
- NCR1
- 蛋白名称
- natural cytotoxicity triggering receptor 1
- 蛋白别名
- Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD antigen CD335
- 靶点基因名
- NCR1
- 基因别名
- LY94
- UniProt
- O76036
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Natural Cytotoxicity Triggering Receptor 1 (NCR1), also known as NKp46, is a protein encoded by the NCR1 gene in humans and is designated as CD335. It is a type I transmembrane receptor belonging to the immunoglobulin superfamily, characterized by two extracellular C2-type Ig-like domains. NCR1 plays a crucial role in activating natural killer (NK) cells to mediate cytotoxicity against tumor and virus-infected cells by associating with ITAM-containing signaling molecules. The gene encoding NCR1 is located on chromosome 19q13.4. In terms of disease, NCR1's role in immune surveillance suggests its potential involvement in cancer, where its function may be exploited for tumor immunotherapy. However, specific disease associations are less detailed compared to its well-characterized role in NK cell activation and cytotoxicity.