人 NBL1 抗体对
01AB04100
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) is a secreted protein that plays a critical role in the regulation of cell growth and differentiation, particularly in the context of neuroblastoma, a common pediatric cancer. NBL1 is part of the transforming growth factor-beta (TGF-β) superfamily and functions as a ligand that can inhibit the proliferation of neuroblastoma cells by promoting apoptosis and differentiation. Its expression is often downregulated in neuroblastoma tumors, contributing to tumorigenesis and poor patient prognosis. In addition to its involvement in neuroblastoma, NBL1 has been implicated in other malignancies, where it may exert tumor-suppressive effects.
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技术参数
- 靶点基因名
- NBL1
- 基因别名
- DAN; DAND1
- 蛋白别名
- NBL1, DAN family BMP antagonist; NBL1
- UniProt
- P41271
- 物种
- Human
产品详情
- 靶点名称
- NBL1
- 蛋白名称
- NBL1, DAN family BMP antagonist
- 蛋白别名
- Neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; Protein N03; Zinc finger protein DAN
- 靶点基因名
- NBL1
- 基因别名
- DAN; DAND1
- UniProt
- P41271
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) is a secreted protein that plays a critical role in the regulation of cell growth and differentiation, particularly in the context of neuroblastoma, a common pediatric cancer. NBL1 is part of the transforming growth factor-beta (TGF-β) superfamily and functions as a ligand that can inhibit the proliferation of neuroblastoma cells by promoting apoptosis and differentiation. Its expression is often downregulated in neuroblastoma tumors, contributing to tumorigenesis and poor patient prognosis. In addition to its involvement in neuroblastoma, NBL1 has been implicated in other malignancies, where it may exert tumor-suppressive effects.