抗人 NAP1L3 抗体对
01AB02439
Nucleosome assembly protein 1 like 3 (NAP1L3) is a nuclear histone chaperone belonging to the nucleosome assembly protein (NAP) family. It plays a critical role in chromatin remodeling and transcriptional regulation by binding core histones and facilitating nucleosome assembly during DNA replication and mitosis. NAP1L3 is particularly essential in hematopoietic stem cells, where it maintains the stem cell pool and regulates proliferation and differentiation. Mechanistically, it influences the expression of key regulatory genes, including MYC, E2F targets, and HOXA clusters. Depletion of NAP1L3 leads to G0 cell-cycle arrest and apoptosis, highlighting its importance in cell-cycle control and genomic stability.
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技术参数
- 靶点基因名
- NAP1L3
- 基因别名
- BNAP
- 蛋白别名
- nucleosome assembly protein 1 like 3; NAP1L3
- UniProt
- Q99457
- 物种
- Human
产品详情
- 靶点名称
- NAP1L3
- 蛋白名称
- nucleosome assembly protein 1 like 3
- 蛋白别名
- Nucleosome assembly protein 1-like 3
- 靶点基因名
- NAP1L3
- 基因别名
- BNAP
- UniProt
- Q99457
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Nucleosome assembly protein 1 like 3 (NAP1L3) is a nuclear histone chaperone belonging to the nucleosome assembly protein (NAP) family. It plays a critical role in chromatin remodeling and transcriptional regulation by binding core histones and facilitating nucleosome assembly during DNA replication and mitosis. NAP1L3 is particularly essential in hematopoietic stem cells, where it maintains the stem cell pool and regulates proliferation and differentiation. Mechanistically, it influences the expression of key regulatory genes, including MYC, E2F targets, and HOXA clusters. Depletion of NAP1L3 leads to G0 cell-cycle arrest and apoptosis, highlighting its importance in cell-cycle control and genomic stability.