人 NAA50 抗体对
01AB00540
N-alpha-acetyltransferase 50 (NAA50) is a catalytic subunit of the NatE complex, involved in N-terminal protein acetylation. It is a 169-amino acid protein with a molecular mass of 19.4 kDa, localized in the cytosol, endoplasmic reticulum, and nucleus. NAA50 has broad substrate specificity, acetylating the initiator methionine of most peptides except those with proline in the second position. It displays N-alpha-acetyltransferase and lysine-epsilon-autoacetyltransferase activities. NAA50 is crucial for development and stress response regulation in plants, and its loss causes severe growth retardation and infertility in Arabidopsis. In humans, NAA50 is important for sister chromatid cohesion and chromosome condensation. Knockdown of NAA50 impairs these processes, emphasizing its role in human health. The enzymatic activity of NAA50 is conserved between humans and plants, with catalytic residues preserved across phototrophic eukaryotes.
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技术参数
- 靶点基因名
- NAA50
- 基因别名
- MAK3; NAT13; NAT5
- 蛋白别名
- N-alpha-acetyltransferase 50, NatE catalytic subunit; NAA50
- UniProt
- Q9GZZ1
- 物种
- Human
产品详情
- 靶点名称
- NAA50
- 蛋白名称
- N-alpha-acetyltransferase 50, NatE catalytic subunit
- 蛋白别名
- N-alpha-acetyltransferase 50; hNaa50p; N-acetyltransferase 13; N-acetyltransferase 5; hNAT5; N-acetyltransferase san homolog; hSAN; N-epsilon-acetyltransferase 50; NatE catalytic subunit
- 靶点基因名
- NAA50
- 基因别名
- MAK3; NAT13; NAT5
- UniProt
- Q9GZZ1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
N-alpha-acetyltransferase 50 (NAA50) is a catalytic subunit of the NatE complex, involved in N-terminal protein acetylation. It is a 169-amino acid protein with a molecular mass of 19.4 kDa, localized in the cytosol, endoplasmic reticulum, and nucleus. NAA50 has broad substrate specificity, acetylating the initiator methionine of most peptides except those with proline in the second position. It displays N-alpha-acetyltransferase and lysine-epsilon-autoacetyltransferase activities. NAA50 is crucial for development and stress response regulation in plants, and its loss causes severe growth retardation and infertility in Arabidopsis. In humans, NAA50 is important for sister chromatid cohesion and chromosome condensation. Knockdown of NAA50 impairs these processes, emphasizing its role in human health. The enzymatic activity of NAA50 is conserved between humans and plants, with catalytic residues preserved across phototrophic eukaryotes.