人 N-terminal Tau 抗体对
01AB03488
N-terminal Tau refers to specific truncated fragments of the tau protein that retain the N-terminal projection domain while lacking C-terminal microtubule-binding regions. These fragments, often terminating near residue 224, are actively secreted by neurons in response to amyloid-beta-induced stress and synaptic dysfunction. Biochemically, they represent the dominant forms of tau circulating in plasma and cerebrospinal fluid due to the rapid degradation of C-terminal regions in blood. Clinically, this marker is emerging as a robust indicator of Alzheimer's disease progression, functioning as a dual marker for both neurofibrillary tangle load and neurodegeneration. It demonstrates high concordance with tau-PET imaging and offers predictive value for cognitive decline and brain atrophy comparable to or exceeding other neurodegeneration markers.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- MAPT
- 基因别名
- MAPTL; MTBT1; TAU
- 蛋白别名
- Microtubule-associated protein tau; N-terminal Tau
- UniProt
- P10636-8
- 物种
- Human
产品详情
- 靶点名称
- N-terminal Tau
- 蛋白名称
- Microtubule-associated protein tau
- 靶点基因名
- MAPT
- 基因别名
- MAPTL; MTBT1; TAU
- UniProt
- P10636-8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
N-terminal Tau refers to specific truncated fragments of the tau protein that retain the N-terminal projection domain while lacking C-terminal microtubule-binding regions. These fragments, often terminating near residue 224, are actively secreted by neurons in response to amyloid-beta-induced stress and synaptic dysfunction. Biochemically, they represent the dominant forms of tau circulating in plasma and cerebrospinal fluid due to the rapid degradation of C-terminal regions in blood. Clinically, this marker is emerging as a robust indicator of Alzheimer's disease progression, functioning as a dual marker for both neurofibrillary tangle load and neurodegeneration. It demonstrates high concordance with tau-PET imaging and offers predictive value for cognitive decline and brain atrophy comparable to or exceeding other neurodegeneration markers.