抗人 MYT1L 抗体对
01AB03891
Myelin transcription factor 1-like protein (MYT1L) is a crucial transcription factor that plays a significant role in neuronal development and differentiation. It is characterized by the presence of C2HC-type zinc fingers and a MYT1 domain, which are thought to function as transcriptional repressors. MYT1L is primarily expressed in the developing brain and is essential for enhancing neuronal identity by actively repressing several developmental pathways, including WNT and NOTCH. Dysregulation of MYT1L has been associated with various neurodevelopmental disorders, particularly autism spectrum disorder (ASD) and intellectual disability. Mutations or deletions in the MYT1L gene can lead to neurodevelopmental delays, behavioral phenotypes, and altered gene expression patterns that resemble those observed in ASD patients.
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技术参数
- 靶点基因名
- MYT1L
- 基因别名
- KIAA1106
- 蛋白别名
- myelin transcription factor 1 like; MYT1L
- UniProt
- Q9UL68
- 物种
- Human
产品详情
- 靶点名称
- MYT1L
- 蛋白名称
- myelin transcription factor 1 like
- 蛋白别名
- Myelin transcription factor 1-like protein; MyT1-L; MyT1L
- 靶点基因名
- MYT1L
- 基因别名
- KIAA1106
- UniProt
- Q9UL68
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Myelin transcription factor 1-like protein (MYT1L) is a crucial transcription factor that plays a significant role in neuronal development and differentiation. It is characterized by the presence of C2HC-type zinc fingers and a MYT1 domain, which are thought to function as transcriptional repressors. MYT1L is primarily expressed in the developing brain and is essential for enhancing neuronal identity by actively repressing several developmental pathways, including WNT and NOTCH. Dysregulation of MYT1L has been associated with various neurodevelopmental disorders, particularly autism spectrum disorder (ASD) and intellectual disability. Mutations or deletions in the MYT1L gene can lead to neurodevelopmental delays, behavioral phenotypes, and altered gene expression patterns that resemble those observed in ASD patients.