人 MYOM2 抗体对
01AB02746
Myomesin 2 (MYOM2) is a major structural protein localized to the sarcomeric M band in striated muscle, where it plays a vital role in crosslinking thick filaments and maintaining myofibrillar integrity. Composed of a unique N-terminal domain followed by twelve fibronectin type III and immunoglobulin-like repeats, MYOM2 facilitates the structural organization of the sarcomere. It interacts with myosin, titin, and light meromyosin, and binds muscle-type creatine kinase (MM-CK) in a dose-dependent and pH-sensitive manner. This interaction effectively couples the mechanical structure of the muscle with local ATP regeneration during contraction. Predominantly expressed in cardiac and fast skeletal muscle, MYOM2 serves as a critical constituent for the stability and physiological function of contractile tissues.
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技术参数
- 靶点基因名
- MYOM2
- 蛋白别名
- myomesin 2; MYOM2
- UniProt
- P54296
- 物种
- Human
产品详情
- 靶点名称
- MYOM2
- 蛋白名称
- myomesin 2
- 蛋白别名
- Myomesin-2; 165 kDa connectin-associated protein; 165 kDa titin-associated protein; M-protein; Myomesin family member 2
- 靶点基因名
- MYOM2
- UniProt
- P54296
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Myomesin 2 (MYOM2) is a major structural protein localized to the sarcomeric M band in striated muscle, where it plays a vital role in crosslinking thick filaments and maintaining myofibrillar integrity. Composed of a unique N-terminal domain followed by twelve fibronectin type III and immunoglobulin-like repeats, MYOM2 facilitates the structural organization of the sarcomere. It interacts with myosin, titin, and light meromyosin, and binds muscle-type creatine kinase (MM-CK) in a dose-dependent and pH-sensitive manner. This interaction effectively couples the mechanical structure of the muscle with local ATP regeneration during contraction. Predominantly expressed in cardiac and fast skeletal muscle, MYOM2 serves as a critical constituent for the stability and physiological function of contractile tissues.