抗人 MYO5C 抗体对
01AB00903
Myosin VC (MYO5C) is a motor protein predominantly expressed in epithelial and glandular tissues, playing a crucial role in secretory processes. It belongs to the class V myosin family and shares approximately 50% sequence identity with myosin Va and Vb. MYO5C functions as a low duty ratio motor, with phosphate release as the rate-limiting step. It consists of a motor domain, an elongated neck domain with six IQ motifs, a coiled-coil dimerization region, and a globular tail domain. MYO5C associates with secretory granules and is involved in transferrin trafficking. It can adopt different conformations and interact with various light chains, including calmodulin, Myl6, and Myl12b. MYO5C has been associated with Griscelli Syndrome Type 1 and Microvillus Inclusion Disease.
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技术参数
- 靶点基因名
- MYO5C
- 蛋白别名
- myosin VC; MYO5C
- UniProt
- Q9NQX4
- 物种
- Human
产品详情
- 靶点名称
- MYO5C
- 蛋白名称
- myosin VC
- 蛋白别名
- Unconventional myosin-Vc
- 靶点基因名
- MYO5C
- UniProt
- Q9NQX4
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Myosin VC (MYO5C) is a motor protein predominantly expressed in epithelial and glandular tissues, playing a crucial role in secretory processes. It belongs to the class V myosin family and shares approximately 50% sequence identity with myosin Va and Vb. MYO5C functions as a low duty ratio motor, with phosphate release as the rate-limiting step. It consists of a motor domain, an elongated neck domain with six IQ motifs, a coiled-coil dimerization region, and a globular tail domain. MYO5C associates with secretory granules and is involved in transferrin trafficking. It can adopt different conformations and interact with various light chains, including calmodulin, Myl6, and Myl12b. MYO5C has been associated with Griscelli Syndrome Type 1 and Microvillus Inclusion Disease.