抗人 MYO16 抗体对
01AB02436
Myosin XVI (MYO16) is a vertebrate-specific, neuronally expressed unconventional myosin predominantly found in neural tissues, especially during late embryonic and early postnatal development when neuronal migration and dendritic elaboration occur. Structurally, MYO16 features an N-terminal ankyrin repeat domain that binds protein phosphatase 1, a myosin motor domain with likely impaired ATPase activity, and a tail domain that interacts with phosphoinositide 3-kinase (PI3K) and the WAVE regulatory complex (WRC), both crucial for actin cytoskeleton dynamics. MYO16 acts as a signal transduction element, integrating pathways that regulate actin reorganization at postsynaptic sites and may also play a role in cell cycle regulation, with two main isoforms: the full-length Myo16b (cytoplasmic and nuclear) and the tailless Myo16a (cytoplasmic). Dysregulation or impaired expression of MYO16 has been associated with neuropsychiatric disorders such as autism, schizophrenia, and bipolar disorder.
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技术参数
- 靶点基因名
- MYO16
- 基因别名
- KIAA0865; MYO16B; NYAP3
- 蛋白别名
- myosin XVI; MYO16
- UniProt
- Q9Y6X6
- 物种
- Human
产品详情
- 靶点名称
- MYO16
- 蛋白名称
- myosin XVI
- 蛋白别名
- Unconventional myosin-XVI; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; Unconventional myosin-16
- 靶点基因名
- MYO16
- 基因别名
- KIAA0865; MYO16B; NYAP3
- UniProt
- Q9Y6X6
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Myosin XVI (MYO16) is a vertebrate-specific, neuronally expressed unconventional myosin predominantly found in neural tissues, especially during late embryonic and early postnatal development when neuronal migration and dendritic elaboration occur. Structurally, MYO16 features an N-terminal ankyrin repeat domain that binds protein phosphatase 1, a myosin motor domain with likely impaired ATPase activity, and a tail domain that interacts with phosphoinositide 3-kinase (PI3K) and the WAVE regulatory complex (WRC), both crucial for actin cytoskeleton dynamics. MYO16 acts as a signal transduction element, integrating pathways that regulate actin reorganization at postsynaptic sites and may also play a role in cell cycle regulation, with two main isoforms: the full-length Myo16b (cytoplasmic and nuclear) and the tailless Myo16a (cytoplasmic). Dysregulation or impaired expression of MYO16 has been associated with neuropsychiatric disorders such as autism, schizophrenia, and bipolar disorder.