人 MXD4 抗体对
01AB02681
MAX dimerization protein 4 (MXD4), also known as MAD4, is a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcriptional repressor that belongs to the MAD gene family. MXD4 heterodimerizes with the MAX protein to form a sequence-specific DNA-binding complex that recognizes the core sequence 5'-CAC[GA]TG-3', thereby repressing transcription. This repression antagonizes MYC transcriptional activity by competing for MAX binding, which is crucial because MYC-MAX complexes act as transcriptional activators. Through this mechanism, MXD4 plays a significant role in regulating cell growth and differentiation, and studies in rodents suggest that MAD family proteins, including MXD4, function as tumor suppressors. Gene Ontology annotations highlight its protein dimerization and transcription corepressor activities. Disease associations for MXD4 include colon sarcoma and bladder sarcoma, indicating that dysregulation of its function may contribute to tumorigenesis, likely due to its role in suppressing MYC-dependent cell transformation.
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技术参数
- 靶点基因名
- MXD4
- 基因别名
- BHLHC12; MAD4
- 蛋白别名
- MAX dimerization protein 4; MXD4
- UniProt
- Q14582
- 物种
- Human
产品详情
- 靶点名称
- MXD4
- 蛋白名称
- MAX dimerization protein 4
- 蛋白别名
- Max dimerization protein 4; Max dimerizer 4; Class C basic helix-loop-helix protein 12; bHLHc12; Max-associated protein 4; Max-interacting transcriptional repressor MAD4
- 靶点基因名
- MXD4
- 基因别名
- BHLHC12; MAD4
- UniProt
- Q14582
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
MAX dimerization protein 4 (MXD4), also known as MAD4, is a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcriptional repressor that belongs to the MAD gene family. MXD4 heterodimerizes with the MAX protein to form a sequence-specific DNA-binding complex that recognizes the core sequence 5'-CAC[GA]TG-3', thereby repressing transcription. This repression antagonizes MYC transcriptional activity by competing for MAX binding, which is crucial because MYC-MAX complexes act as transcriptional activators. Through this mechanism, MXD4 plays a significant role in regulating cell growth and differentiation, and studies in rodents suggest that MAD family proteins, including MXD4, function as tumor suppressors. Gene Ontology annotations highlight its protein dimerization and transcription corepressor activities. Disease associations for MXD4 include colon sarcoma and bladder sarcoma, indicating that dysregulation of its function may contribute to tumorigenesis, likely due to its role in suppressing MYC-dependent cell transformation.