抗人 MTFR1 抗体对
01AB02724
Mitochondrial fission regulator 1 (MTFR1) is a nuclear-encoded protein that localizes to the mitochondria, where it plays a significant role in regulating mitochondrial organization, aerobic respiration, and fission. It is involved in shaping mitochondrial cristae and maintaining respiratory efficiency, likely by coordinating with the core mitochondrial fission and fusion machinery to adjust the mitochondrial network architecture in response to metabolic demands. By influencing mitochondrial morphology and dynamics, MTFR1 ensures that the organelle's structure is optimized for cellular energy production. While perturbations in mitochondrial dynamics are central to various neurodegenerative and metabolic conditions, there are currently no well-established, specific monogenic diseases directly attributed to MTFR1 mutations. It is primarily recognized for its fundamental role in maintaining mitochondrial homeostasis and its potential as a modifier of mitochondrial dysfunction-associated pathologies.
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技术参数
- 靶点基因名
- MTFR1
- 基因别名
- CHPPR; FAM54A2; KIAA0009
- 蛋白别名
- mitochondrial fission regulator 1; MTFR1
- UniProt
- Q15390
- 物种
- Human
产品详情
- 靶点名称
- MTFR1
- 蛋白名称
- mitochondrial fission regulator 1
- 蛋白别名
- Mitochondrial fission regulator 1; Chondrocyte protein with a poly-proline region
- 靶点基因名
- MTFR1
- 基因别名
- CHPPR; FAM54A2; KIAA0009
- UniProt
- Q15390
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Mitochondrial fission regulator 1 (MTFR1) is a nuclear-encoded protein that localizes to the mitochondria, where it plays a significant role in regulating mitochondrial organization, aerobic respiration, and fission. It is involved in shaping mitochondrial cristae and maintaining respiratory efficiency, likely by coordinating with the core mitochondrial fission and fusion machinery to adjust the mitochondrial network architecture in response to metabolic demands. By influencing mitochondrial morphology and dynamics, MTFR1 ensures that the organelle's structure is optimized for cellular energy production. While perturbations in mitochondrial dynamics are central to various neurodegenerative and metabolic conditions, there are currently no well-established, specific monogenic diseases directly attributed to MTFR1 mutations. It is primarily recognized for its fundamental role in maintaining mitochondrial homeostasis and its potential as a modifier of mitochondrial dysfunction-associated pathologies.