人 MTCL1 抗体对
01AB03143
Microtubule crosslinking factor 1 (MTCL1) is a microtubule-associated protein characterized by two independent microtubule-binding regions at its N- and C-termini, enabling it to crosslink and stabilize non-centrosomal microtubules, particularly in polarized epithelial cells. MTCL1 plays a critical role in organizing microtubule networks by accumulating microtubules along the lateral membrane and facilitating the formation of stable, Golgi-associated microtubule arrays essential for Golgi ribbon structure and function. It acts as a scaffold protein, recruiting and interacting with other regulatory proteins such as PAR-1b, CLASPs, and AKAP450/CG-NAP to maintain microtubule dynamics and cellular polarity. Disruption or knockdown of MTCL1 impairs the development of apicobasal microtubule bundles, leading to defects in cell polarity and Golgi organization. Its essential role in cytoskeletal organization suggests that its dysfunction could contribute to pathological states involving impaired cell polarity or intracellular transport.
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技术参数
- 靶点基因名
- MTCL1
- 基因别名
- CCDC165; KIAA0802; SOGA2
- 蛋白别名
- microtubule crosslinking factor 1; MTCL1
- UniProt
- Q9Y4B5
- 物种
- Human
产品详情
- 靶点名称
- MTCL1
- 蛋白名称
- microtubule crosslinking factor 1
- 蛋白别名
- Microtubule cross-linking factor 1; Coiled-coil domain-containing protein 165; PAR-1-interacting protein; SOGA family member 2
- 靶点基因名
- MTCL1
- 基因别名
- CCDC165; KIAA0802; SOGA2
- UniProt
- Q9Y4B5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Microtubule crosslinking factor 1 (MTCL1) is a microtubule-associated protein characterized by two independent microtubule-binding regions at its N- and C-termini, enabling it to crosslink and stabilize non-centrosomal microtubules, particularly in polarized epithelial cells. MTCL1 plays a critical role in organizing microtubule networks by accumulating microtubules along the lateral membrane and facilitating the formation of stable, Golgi-associated microtubule arrays essential for Golgi ribbon structure and function. It acts as a scaffold protein, recruiting and interacting with other regulatory proteins such as PAR-1b, CLASPs, and AKAP450/CG-NAP to maintain microtubule dynamics and cellular polarity. Disruption or knockdown of MTCL1 impairs the development of apicobasal microtubule bundles, leading to defects in cell polarity and Golgi organization. Its essential role in cytoskeletal organization suggests that its dysfunction could contribute to pathological states involving impaired cell polarity or intracellular transport.