人 MST1 抗体对
01AB02082
Macrophage stimulating 1 (MST1) is a secreted plasma protein structurally related to hepatocyte growth factor. It is synthesized as a single-chain precursor and proteolytically cleaved into disulfide-linked alpha and beta chains to become biologically active. MST1 signals primarily through the RON (MST1R) receptor tyrosine kinase, regulating diverse cellular processes including macrophage activation, epithelial cell dissociation, and ciliary motility. In the nervous system, it acts as a neurotrophic factor for cranial motoneurons, supporting neuronal survival and limiting inflammatory damage. Clinically, MST1 is associated with immunodeficiency 14 and primary sclerosing cholangitis. Dysregulation of the MST1–RON signaling axis is also implicated in the progression of various cancers and chronic inflammatory responses, where it modulates the behavior of both epithelial cells and the innate immune system.
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技术参数
- 靶点基因名
- MST1
- 基因别名
- D3F15S2; DNF15S2; HGFL
- 蛋白别名
- macrophage stimulating 1; MST1
- UniProt
- P26927
- 物种
- Human
产品详情
- 靶点名称
- MST1
- 蛋白名称
- macrophage stimulating 1
- 蛋白别名
- Hepatocyte growth factor-like protein; Macrophage stimulatory protein; Macrophage-stimulating protein; MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain]
- 靶点基因名
- MST1
- 基因别名
- D3F15S2; DNF15S2; HGFL
- UniProt
- P26927
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Macrophage stimulating 1 (MST1) is a secreted plasma protein structurally related to hepatocyte growth factor. It is synthesized as a single-chain precursor and proteolytically cleaved into disulfide-linked alpha and beta chains to become biologically active. MST1 signals primarily through the RON (MST1R) receptor tyrosine kinase, regulating diverse cellular processes including macrophage activation, epithelial cell dissociation, and ciliary motility. In the nervous system, it acts as a neurotrophic factor for cranial motoneurons, supporting neuronal survival and limiting inflammatory damage. Clinically, MST1 is associated with immunodeficiency 14 and primary sclerosing cholangitis. Dysregulation of the MST1–RON signaling axis is also implicated in the progression of various cancers and chronic inflammatory responses, where it modulates the behavior of both epithelial cells and the innate immune system.