人 MSR1 抗体对
01AB04097
Macrophage scavenger receptor types I and II (MSR1) is a membrane glycoprotein that plays a crucial role in the immune response by mediating the endocytosis of modified lipoproteins and other macromolecules. Encoded by the MSR1 gene, it exists in multiple isoforms, primarily types I and II, which are functional receptors involved in lipid metabolism and the clearance of cellular debris. MSR1 is predominantly expressed on macrophages but can also be found in other cell types, including dendritic cells. Dysregulation of MSR1 has been implicated in various diseases, particularly atherosclerosis, where it contributes to foam cell formation and plaque development. Additionally, its role in Alzheimer's disease has been noted, as it may facilitate the uptake of amyloid-beta peptides.
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技术参数
- 靶点基因名
- MSR1
- 基因别名
- SCARA1
- 蛋白别名
- macrophage scavenger receptor 1; MSR1
- UniProt
- P21757
- 物种
- Human
产品详情
- 靶点名称
- MSR1
- 蛋白名称
- macrophage scavenger receptor 1
- 蛋白别名
- Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD antigen CD204
- 靶点基因名
- MSR1
- 基因别名
- SCARA1
- UniProt
- P21757
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Macrophage scavenger receptor types I and II (MSR1) is a membrane glycoprotein that plays a crucial role in the immune response by mediating the endocytosis of modified lipoproteins and other macromolecules. Encoded by the MSR1 gene, it exists in multiple isoforms, primarily types I and II, which are functional receptors involved in lipid metabolism and the clearance of cellular debris. MSR1 is predominantly expressed on macrophages but can also be found in other cell types, including dendritic cells. Dysregulation of MSR1 has been implicated in various diseases, particularly atherosclerosis, where it contributes to foam cell formation and plaque development. Additionally, its role in Alzheimer's disease has been noted, as it may facilitate the uptake of amyloid-beta peptides.