抗人 MRP2 抗体对
01AB02375
ATP binding cassette subfamily C member 2 (MRP2) is an ATP-dependent efflux transporter that mediates the export of a wide range of organic anions, including conjugated bilirubin, bile salts, and various drug conjugates. It is predominantly localized to the apical membrane of hepatocytes, as well as the renal proximal tubule and intestinal epithelial cells, where it facilitates hepatic detoxification and biliary excretion. Structurally, MRP2 consists of two transmembrane domains, two nucleotide-binding domains, and a regulatory domain that modulates substrate selectivity and transport activity. This transporter plays a critical role in chemoprotection and drug disposition. Pathogenic variants in the ABCC2 gene cause Dubin-Johnson syndrome, a condition characterized by conjugated hyperbilirubinemia. Additionally, alterations in MRP2 expression or function are associated with multidrug resistance in various cancers.
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技术参数
- 靶点基因名
- ABCC2
- 基因别名
- CMOAT; CMOAT1; CMRP; MRP2
- 蛋白别名
- ATP binding cassette subfamily C member 2; MRP2
- UniProt
- Q92887
- 物种
- Human
产品详情
- 靶点名称
- MRP2
- 蛋白名称
- ATP binding cassette subfamily C member 2
- 蛋白别名
- ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2
- 靶点基因名
- ABCC2
- 基因别名
- CMOAT; CMOAT1; CMRP; MRP2
- UniProt
- Q92887
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
ATP binding cassette subfamily C member 2 (MRP2) is an ATP-dependent efflux transporter that mediates the export of a wide range of organic anions, including conjugated bilirubin, bile salts, and various drug conjugates. It is predominantly localized to the apical membrane of hepatocytes, as well as the renal proximal tubule and intestinal epithelial cells, where it facilitates hepatic detoxification and biliary excretion. Structurally, MRP2 consists of two transmembrane domains, two nucleotide-binding domains, and a regulatory domain that modulates substrate selectivity and transport activity. This transporter plays a critical role in chemoprotection and drug disposition. Pathogenic variants in the ABCC2 gene cause Dubin-Johnson syndrome, a condition characterized by conjugated hyperbilirubinemia. Additionally, alterations in MRP2 expression or function are associated with multidrug resistance in various cancers.