人 MRGBP 抗体对
01AB02615
MRG domain binding protein (MRGBP) is a nuclear subunit of the NuA4/TRRAP-TIP60 histone acetyltransferase complex, which regulates chromatin structure and gene expression by acetylating histones H4 and H2A. Through its role in the NuA4 complex, MRGBP participates in transcriptional programs related to cell proliferation, DNA repair, and apoptosis. It specifically modulates DNA double-strand break repair by limiting DNA-end resection, thereby restraining homologous recombination and non-homologous end joining to maintain genome stability. Clinically, MRGBP is overexpressed in several malignancies and has been proposed as a prognostic biomarker in head and neck squamous cell carcinoma, where high expression levels correlate with poor clinical outcomes.
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技术参数
- 靶点基因名
- MRGBP
- 基因别名
- C20orf20
- 蛋白别名
- MRG domain binding protein; MRGBP
- UniProt
- Q9NV56
- 物种
- Human
产品详情
- 靶点名称
- MRGBP
- 蛋白名称
- MRG domain binding protein
- 蛋白别名
- MRG/MORF4L-binding protein; MRG-binding protein; Up-regulated in colon cancer 4; Urcc4
- 靶点基因名
- MRGBP
- 基因别名
- C20orf20
- UniProt
- Q9NV56
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
MRG domain binding protein (MRGBP) is a nuclear subunit of the NuA4/TRRAP-TIP60 histone acetyltransferase complex, which regulates chromatin structure and gene expression by acetylating histones H4 and H2A. Through its role in the NuA4 complex, MRGBP participates in transcriptional programs related to cell proliferation, DNA repair, and apoptosis. It specifically modulates DNA double-strand break repair by limiting DNA-end resection, thereby restraining homologous recombination and non-homologous end joining to maintain genome stability. Clinically, MRGBP is overexpressed in several malignancies and has been proposed as a prognostic biomarker in head and neck squamous cell carcinoma, where high expression levels correlate with poor clinical outcomes.